ArticleAnnals of internal medicine2016
Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening: A Modeling Study.
Article in Annals of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the "Bexa™" Breast Examination (BBE) as an Effective Solution to Breast Cancer Early Detection
Evaluation of the Bexa Breast Examination (BBE) as an Effective Solution to Breast Cancer Early Detection
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Evidence of cancer: a systematic review of metabolomics in extracellular vesicles for cancer biomarker detection.Metabolomics : Official journal of the Metabolomic Society · 2025Pooled it
- Benefits and harms of annual, biennial, or triennial breast cancer mammography screening for women at average risk of breast cancer: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC).British journal of cancer · 2022Pooled it
- Portable, real-time 3D ultrasound for operator-independent breast imaging.Nature communications · 2026Article
- Implant-displacement views alone for breast cancer screening in women with implants: a multicenter retrospective study.European radiology · 2026Article
- Range of Normalized Glandular Dose for Mammography Using Patient-Specific Glandular Fractions.ArXiv · 2026Article
- Utilizing post-imaging surveys to guide development of photoacoustic computed technology for breast imaging.American journal of surgery · 2026Article
- Radiation Risk in 2D Mammography Screening: A Scoping Review of Modelling Strategies and Emerging AI Applications.Journal of medical radiation sciences · 2026Article
- Patient-Specific Normalized Glandular Dose Range Estimate For Mammography.Research square · 2026Article
- BMagnetic resonance in medicine · 2025Article
- Local Diagnostic Reference Levels in Digital Breast Tomosynthesis.Journal of medical radiation sciences · 2025Article
- The TESTBREAST journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer.International journal of cancer · 2025Article
- Tumor localization strategies of multicancer early detection tests: a quantitative assessment.JNCI cancer spectrum · 2025Article
- Multilayer analysis of ethnically diverse blood and urine biomarkers for breast cancer risk and prognosis.Scientific reports · 2025Article
- Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure.Diagnostics (Basel, Switzerland) · 2025Article
- Mammographic screening: hero or villain.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Understanding the risk of ionizing radiation in breast imaging: Concepts and quantities, clinical importance, and future directions.European journal of radiology · 2024Review
- Evaluating Factors Affecting Mean Glandular Dose in Mammography: Insights from a Retrospective Study in Dubai.Diagnostics (Basel, Switzerland) · 2024Article
- Screening Mammography Diagnostic Reference Level System According to Compressed Breast Thickness: Dubai Health.Journal of imaging · 2024Article
- Screening for Breast Cancer: A Comparative Review of Guidelines.Life (Basel, Switzerland) · 2024Review
- Assessment of medical students' knowledge regarding radiation associated risk and its protection: finding from a cross-sectional study.Irish journal of medical science · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEstimates of risk for radiation-induced breast cancer from mammography screening have not considered variation in dose exposure or diagnostic work-up after abnormal screening results.
objectiveTo estimate distributions of radiation-induced breast cancer incidence and mortality from digital mammography screening while considering exposure from screening and diagnostic mammography and dose variation among women.
design2 simulation-modeling approaches.
settingU.S. population. PATIENTS: Women aged 40 to 74 years.
interventionAnnual or biennial digital mammography screening from age 40, 45, or 50 years until age 74 years. MEASUREMENTS: Lifetime breast cancer deaths averted (benefits) and radiation-induced breast cancer incidence and mortality (harms) per 100,000 women screened.
resultsAnnual screening of 100,000 women aged 40 to 74 years was projected to induce 125 breast cancer cases (95% CI, 88 to 178) leading to 16 deaths (CI, 11 to 23), relative to 968 breast cancer deaths averted by early detection from screening. Women exposed at the 95th percentile were projected to develop 246 cases of radiation-induced breast cancer leading to 32 deaths per 100,000 women. Women with large breasts requiring extra views for complete examination (8% of population) were projected to have greater radiation-induced breast cancer risk (266 cancer cases and 35 deaths per 100,000 women) than other women (113 cancer cases and 15 deaths per 100,000 women). Biennial screening starting at age 50 years reduced risk for radiation-induced cancer 5-fold. LIMITATION: Life-years lost from radiation-induced breast cancer could not be estimated.
conclusionRadiation-induced breast cancer incidence and mortality from digital mammography screening are affected by dose variability from screening, resultant diagnostic work-up, initiation age, and screening frequency. Women with large breasts may have a greater risk for radiation-induced breast cancer. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality, U.S. Preventive Services Task Force, National Cancer Institute.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.