Evidence map›Paper›PMID 26756417›Full record

ArticleProteomics. Clinical applications2016

Differential protein expression and basal lamina remodeling in human heart failure.

Evelyn H Kim, Vladimir I Galchev, Jin Young Kim, Sean A Misek, Tamara K Stevenson, Matthew D Campbell, Francis D Pagani, Sharlene M Day, T Craig Johnson, Joseph G Washburn and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomics. Clinical applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Evelyn H KimDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Vladimir I GalchevDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Jin Young KimKorea Basic Science Institute, Ochang, Korea.
Sean A MisekDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA.
Tamara K StevensonDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA.
Matthew D CampbellDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Francis D PaganiDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA.
Sharlene M DayCardiovascular Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
T Craig JohnsonDNA Sequencing and Microarray Facility, University of Michigan, Ann Arbor, MI, USA.
Joseph G WashburnDNA Sequencing and Microarray Facility, University of Michigan, Ann Arbor, MI, USA.
Karen L VikstromCardiovascular Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Daniel E MicheleDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
David E MisekDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Margaret V WestfallDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USMichigan Medicine · USKorea Basic Science Institute · KR

Funding

PUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Research DevelopmentP30AG013283 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, RICHARD A · 1995 to 2014
$12.3M
SYTEMS AND INTEGRATIVE BIOLOGYT32GM008322 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 1990 to 2020
$5.7M
PKC Troponin I phosphorylation &contractile functionR01HL067254 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WESTFALL, MARGARET V · 2002 to 2010
$2.3M
Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma DetectionR01CA140211 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISEK, DAVID E · 2009 to 2013
$1.6M
Protein Expression in Failing Human HeartsR21HL089193 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WESTFALL, MARGARET V · 2009 to 2010
$425k
NCI NIH HHS R01 CA140211NHLBI NIH HHS R01 HL067254NHLBI NIH HHS R21 HL089193NIA NIH HHS P30 AG013283NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P60 DK020572NIGMS NIH HHS T32 GM008322
6 · The paper itself

Abstract

purposeA goal of this study was to identify and investigate previously unrecognized components of the remodeling process in the progression to heart failure by comparing protein expression in ischemic failing (F) and nonfailing (NF) human hearts. EXPERIMENTAL

designProtein expression differences were investigated using multidimensional protein identification and validated by Western analysis. This approach detected basal lamina (BL) remodeling, and further studies analyzed samples for evidence of structural BL remodeling. A rat model of pressure overload (PO) was studied to determine whether nonischemic stressors also produce BL remodeling and impact cellular adhesion.

resultsDifferential protein expression of collagen IV, laminin α2, and nidogen-1 indicated BL remodeling develops in F versus NF hearts Periodic disruption of cardiac myocyte BL accompanied this process in F, but not NF heart. The rat PO myocardium also developed BL remodeling and compromised myocyte adhesion compared to sham controls. CONCLUSIONS AND CLINICAL RELEVANCE: Differential protein expression and evidence of structural and functional BL alterations develop during heart failure. The compromised adhesion associated with this remodeling indicates a high potential for dysfunctional cellular integrity and tethering in failing myocytes. Therapeutically targeting BL remodeling could slow or prevent the progression of heart disease.

Indexed as

AgedAnimalsBasement MembraneCollagen Type IVDisease Models, AnimalGene Expression ProfilingGene Expression RegulationHeart FailureHumansLamininMembrane GlycoproteinsMiddle AgedMyocardial IschemiaMyocardiumMyocytes, CardiacPrimary Cell CultureCollagen Type IVLamininlaminin alpha 2Membrane GlycoproteinsnidogenBasal laminaHeart failureMyocardiumProteinsRemodeling

Identifiers

PMID26756417
PMCPMC5524561
OpenAlexW2239629461

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.