Trial reportThe Laryngoscope2016
Multicenter clinical trial of the Nucleus Hybrid S8 cochlear implant: Final outcomes.
Trial report in The Laryngoscope, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04707885 (Clinical Utility of Residual Hearing in the Cochlear Implant Ear), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Utility of Residual Hearing in the Cochlear Implant Ear
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electrocochleography in Cochlear Implant Users with Residual Acoustic Hearing: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Influence of Electric Frequency-to-Place Mismatches on the Early Speech Recognition Outcomes for Electric-Acoustic Stimulation Users.American journal of audiology · 2023Trial
- Nucleus Hybrid S12: Multicenter Clinical Trial Results.The Laryngoscope · 2020Trial
- Bilateral Cochlear Implants Using Two Electrode Lengths in Infants With Profound Deafness.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019Trial
- Outcomes of Adolescents With a Short Electrode Cochlear Implant With Preserved Residual Hearing.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2016Trial
- Comparative spatiotemporal dynamics of access resistance, polarization impedance, and nested bipolar impedance in standard and dexamethasone-eluting electrode arrays.Hearing research · 2026Article
- Robotic-Assisted Electrode Array Insertion Improves Stability of Acoustic Hearing Thresholds.The Laryngoscope · 2026Article
- Factors Affecting Audiometric and Speech Perception Outcomes in Hybrid Cochlear Implant Recipients.The Laryngoscope · 2026Article
- Spatiotemporal Dynamics of Cochlear Implant Electrode Impedance in Standard and Dexamethasone-Eluting Electrode Arrays.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Robotic-Assisted Electrode Array Insertion Improves Rates of Hearing Preservation.The Laryngoscope · 2025Article
- An arbitrary waveform neurostimulator for preclinical studies: design and verification.Medical & biological engineering & computing · 2025Article
- Interaural correlation of acoustic hearing preservation following sequential cochlear implantation.Frontiers in neurology · 2025Article
- Age-Related Hearing Loss: Evidence-Based Strategies for Early Detection and Management.ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses · 2025Article
- Two different methods to digitally visualize continuous electrocochleography potentials during cochlear implantation: a first description of feasibility.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants.ACS applied bio materials · 2024Article
- Clinical Applications of Intracochlear Electrocochleography in Cochlear Implant Users With Residual Acoustic Hearing.Journal of audiology & otology · 2024Article
- American Cochlear Implant Alliance Task Force: Recommendations for Determining Cochlear Implant Candidacy in Adults.The Laryngoscope · 2024Article
- Spectral Grouping of Electrically Encoded Sound Predicts Speech-in-Noise Performance in Cochlear Implantees.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Evaluation of Real-Time Intracochlear Electrocochleography for Guiding Cochlear Implant Electrode Array Position.Journal of clinical medicine · 2023Article
- Evaluation of the Performance of OTOPLAN-Based Cochlear Implant Electrode Array Selection: A Retrospective Study.Journal of personalized medicine · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectives/hypothesisThe concept of expanding electrical speech processing to those with more residual acoustic hearing with a less-invasive shorter cochlear implant (CI) has been ongoing since 1999. A multicenter study of the Nucleus Hybrid S8 CI took place between 2002 and 2011. This report describes the final outcomes of this clinical trial. STUDY
designMulticenter, longitudinal, single-subject design.
methodsEighty-seven subjects received a Nucleus Hybrid S8 CI in their poorer ear. Speech perception in quiet (Consonant-Nucleus-Consonant [CNC] words) and in noise (Bamford-Kowal-Bench Sentences-In-Noise [BKB-SIN]) were collected pre- and postoperatively at 3, 6, and 12 months. Subjective questionnaire data using the Abbreviated Profile for Hearing Aid Benefit (APHAB) were also collected.
resultsSome level of hearing preservation was accomplished in 98% subjects, with 90% maintaining a functional low-frequency pure-tone average (LFPTA) at initial activation. By 12 months, five subjects had total hearing loss, and 80% of subjects maintained functional hearing. CNC words demonstrated that 82.5% and 87.5% of subjects had significant improvements in the hybrid and combined conditions, respectively. The majority had improvements with BKB-SIN. Results also indicated that as long as subjects maintained at least a severe LFPTA, there was significant improvement in speech understanding. Furthermore, all subjects reported positive improvements in hearing in three of the four subscales of the APHAB.
conclusionsThe concept of hybrid speech processing has significant advantages for subjects with residual low-frequency hearing. In this study, the Nucleus Hybrid S8 provided improved word understanding in quiet and noise. Additionally, there appears to be stability of the residual hearing after initial activation of the device. LEVEL OF EVIDENCE: 2c.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.