Evidence map›Paper›PMID 26756163›Full record

ArticleDepression and anxiety2016

SPECIFIC MOOD SYMPTOMS CONFER RISK FOR SUBSEQUENT SUICIDAL IDEATION IN BIPOLAR DISORDER WITH AND WITHOUT SUICIDE ATTEMPT HISTORY: MULTI-WAVE DATA FROM STEP-BD.

Jonathan P Stange, Evan M Kleiman, Louisa G Sylvia, Pedro Vieira da Silva Magalhães, Michael Berk, Andrew A Nierenberg, Thilo Deckersbach

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Jonathan P StangeDepartment of Psychology, Temple University, Philadelphia, Pennsylvania.
Evan M KleimanDepartment of Psychology, Harvard University, Cambridge, Massachusetts.
Louisa G SylviaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Pedro Vieira da Silva MagalhãesNational Institute for Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
Michael BerkIMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Victoria, Australia.
Andrew A NierenbergDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Thilo DeckersbachDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Massachusetts General Hospital · USDeakin University · AUHarvard University · USHarvard University Press · USTemple University · USUniversidade Federal do Rio Grande do Sul · BR

Funding

TREATMENT OF BIPOLAR DISORDER-278980001N01MH080001 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · 1998 to 2003
$5.3M
Cognitive-Behavior Therapy for Bipolar DisorderK23MH074895 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DECKERSBACH, THILO · 2007 to 2011
$973k
Inflexibility and Vulnerability to DepressionF31MH099761 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI STANGE, JONATHAN P · 2012 to 2014
$87k
NIMH NIH HHS F31 MH099761NIMH NIH HHS K23 MH074895NIMH NIH HHS N01 MH080001
6 · The paper itself

Abstract

backgroundLittle is known about specific mood symptoms that may confer risk for suicidal ideation (SI) among patients with bipolar disorder (BD). We evaluated prospectively whether particular symptoms of depression and mania precede the onset or worsening of SI, among adults with or without a history of a suicide attempt.

methodsWe examined prospective data from a large (N = 2,741) cohort of patients participating in the Systematic Treatment Enhancement Program for BD (STEP-BD). We evaluated history of suicide attempts at baseline, and symptoms of depression and mania at baseline and follow-up visits. Hierarchical linear modeling tested whether specific mood symptoms predicted subsequent levels of SI, and whether the strength of the associations differed based on suicide attempt history, after accounting for the influence of other mood symptoms and current SI.

resultsBeyond overall current depression and mania symptom severity, baseline SI, and illness characteristics, several mood symptoms, including guilt, reduced self-esteem, psychomotor retardation and agitation, increases in appetite, and distractibility predicted more severe levels of subsequent SI. Problems with concentration, distraction, sleep loss and decreased need for sleep predicted subsequent SI more strongly among individuals with a suicide attempt history.

conclusionsSeveral specific mood symptoms may confer risk for the onset or worsening of SI among treatment-seeking patients with BD. Individuals with a previous suicide attempt may be at greater risk in part due to greater reactivity to certain mood symptoms in the form of SI. However, overall, effect sizes were small, suggesting the need to identify additional proximal predictors of SI.

Indexed as

Suicidal IdeationSuicide, AttemptedAdultBipolar DisorderFemaleFollow-Up StudiesHumansMaleMiddle AgedMood DisordersRiskbipolar disordercognitiondepressionmood disorderssuicide/self-harm

Identifiers

PMID26756163
PMCPMC4889534
OpenAlexW2235709159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.