Evidence map›Paper›PMID 26756157›Full record

Trial reportOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2016

Initial Results With Image-guided Cochlear Implant Programming in Children.

Jack H Noble, Andrea J Hedley-Williams, Linsey Sunderhaus, Benoit M Dawant, Robert F Labadie, Stephen M Camarata, René H Gifford

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Article
  3. Cochlear Implant Electrode Placement and Music Perception.JAMA otolaryngology-- head & neck surgery · 2025
    Article
  4. Article
  5. Electrically evoked compound action potentials are associated with the site of intracochlear stimulation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  6. Article
  7. Article
  8. Super-resolution segmentation network for inner-ear tissue segmentation.Simulation and synthesis in medical imaging : ... International Workshop, SASHIMI ..., held in conjunction with MICCAI ..., proceedings. SASHIMI (Workshop) · 2023
    Article
  9. A Unified Deep-Learning-Based Framework for Cochlear Implant Electrode Array Localization.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Auditory performance of post-lingually deafened adult cochlear implant recipients using electrode deactivation based on postoperative cone beam CT images.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  18. Atlas-based segmentation of cochlear microstructures in cone beam CT.International journal of computer assisted radiology and surgery · 2021
    Article
  19. Auditory Nerve Fiber Health Estimation Using Patient Specific Cochlear Implant Stimulation Models.Simulation and synthesis in medical imaging : ... International Workshop, SASHIMI ..., held in conjunction with MICCAI ..., proceedings. SASHIMI (Workshop) · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jack H Noble*Department of Electrical Engineering and Computer Science, Vanderbilt University †Department of Hearing and Speech Science ‡Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.
Andrea J Hedley-Williams
Linsey Sunderhaus
Benoit M Dawant
Robert F Labadie
Stephen M Camarata
René H Gifford
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Research Supplements to Promote Diversity in Health-Related ResearchR01DC008408 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LABADIE, ROBERT F · 2007 to 2022
$7.6M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALLACE, MARK THOMAS · 2015 to 2019
$7.1M
Model-based Cochlear Implant ProgrammingR01DC014037 · NIDCD · VANDERBILT UNIVERSITY · PI NOBLE, JACK · 2014 to 2024
$5.0M
Clinical Application of Spectral Envelope Perception: Cochlear Implant EvaluationR01DC013117 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GIFFORD, RENE H · 2013 to 2017
$1.6M
Image-based frequency reallocation for optimizing cochlear implant programmingR21DC012620 · NIDCD · VANDERBILT UNIVERSITY · PI NOBLE, JACK · 2012 to 2013
$408k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NICHD NIH HHS U54 HD083211NIDCD NIH HHS R01 DC008408NIDCD NIH HHS R01DC008408NIDCD NIH HHS R01 DC013117NIDCD NIH HHS R01 DC014037NIDCD NIH HHS R01DC014037NIDCD NIH HHS R01DC13117NIDCD NIH HHS R21 DC012620NIDCD NIH HHS R21DC012620
6 · The paper itself

Abstract

hypothesisImage-guided cochlear implant (CI) programming can improve hearing outcomes for pediatric CI recipients.

backgroundCIs have been highly successful for children with severe-to-profound hearing loss, offering potential for mainstreamed education and auditory-oral communication. Despite this, a significant number of recipients still experience poor speech understanding, language delay, and, even among the best performers, restoration to normal auditory fidelity is rare. Although significant research efforts have been devoted to improving stimulation strategies, few developments have led to significant hearing improvement over the past two decades. Recently introduced techniques for image-guided CI programming (IGCIP) permit creating patient-customized CI programs by making it possible, for the first time, to estimate the position of implanted CI electrodes relative to the nerves they stimulate using CT images. This approach permits identification of electrodes with high levels of stimulation overlap and to deactivate them from a patient's map. Previous studies have shown that IGCIP can significantly improve hearing outcomes for adults with CIs.

methodsThe IGCIP technique was tested for 21 ears of 18 pediatric CI recipients. Participants had long-term experience with their CI (5 mo to 13 yr) and ranged in age from 5 to 17 years old. Speech understanding was assessed after approximately 4 weeks of experience with the IGCIP map.

resultsUsing a two-tailed Wilcoxon signed-rank test, statistically significant improvement (p < 0.05) was observed for word and sentence recognition in quiet and noise, as well as pediatric self-reported quality-of-life (QOL) measures.

conclusionOur results indicate that image guidance significantly improves hearing and QOL outcomes for pediatric CI recipients.

Indexed as

Cochlear ImplantsSoftwareAdolescentAdultChildCochleaCochlear ImplantationFemaleHearingHumansInfantLanguageMaleRadiographic Image Interpretation, Computer-AssistedTomography, X-Ray Computed

Identifiers

PMID26756157
PMCPMC4849538
OpenAlexW2425760839

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.