Evidence map›Paper›PMID 26756114›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

FSH Levels Predict Bone Loss in Premenopausal Women Treated for Breast Cancer More Than One Year After Treatment.

Laila S Tabatabai, Joan Bloom, Susan Stewart, Deborah E Sellmeyer

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Modulation of Gonadotropins Activity by Antibodies.Frontiers in endocrinology · 2019
    Review
  3. Frontiers in endocrinology · 2018
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Laila S TabatabaiDivision of Endocrinology (L.S.T., D.E.S.), Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21224; Department of Health Policy and Management (J.B.), School of Public Health, University of California, Berkeley, California 94720; and Department of Public Health Sciences (S.S.), School of Medicine, University of California, Davis, California 95616.
Joan BloomDivision of Endocrinology (L.S.T., D.E.S.), Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21224; Department of Health Policy and Management (J.B.), School of Public Health, University of California, Berkeley, California 94720; and Department of Public Health Sciences (S.S.), School of Medicine, University of California, Davis, California 95616.
Susan StewartDivision of Endocrinology (L.S.T., D.E.S.), Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21224; Department of Health Policy and Management (J.B.), School of Public Health, University of California, Berkeley, California 94720; and Department of Public Health Sciences (S.S.), School of Medicine, University of California, Davis, California 95616.
Deborah E SellmeyerDivision of Endocrinology (L.S.T., D.E.S.), Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21224; Department of Health Policy and Management (J.B.), School of Public Health, University of California, Berkeley, California 94720; and Department of Public Health Sciences (S.S.), School of Medicine, University of California, Davis, California 95616.
Johns Hopkins Hospital · USJohns Hopkins University · USUniversity of California, Berkeley · USUniversity of California, Davis · US

Funding

Exercise for Bone Health: Young Breast Cancer SurvivorsR01CA112273 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BLOOM, JOAN R · 2005 to 2009
$3.5M
NCI NIH HHS R01 CA112273NCI NIH HHS R01CA112273NCI NIH HHS R01CA112273-03S1
6 · The paper itself

Abstract

contextBiomarkers to predict bone loss in premenopausal women after breast cancer treatment have not been examined.

objectiveTo determine whether baseline FSH predicts subsequent bone loss.

designSecondary data analysis of the Exercise for Bone Health: Young Breast Cancer Survivors study, in which women were randomized to a 12-month exercise program or monthly health newsletter.

settingCommunity dwelling women.

participantsA total of 206 women age less than or equal to 55 years at breast cancer diagnosis who had received adjuvant chemotherapy and were at least 1 year after diagnosis.

interventionSerum collected at baseline (an average of 302 ± 148 d after completing chemotherapy) was analyzed for FSH.

main outcome measureChange in bone mineral density.

resultsIn linear regression models, baseline FSH levels predicted bone loss over the ensuing 12 months at the lumbar spine and femoral neck including after adjustment for age, ethnicity, treatment group (exercise vs control), baseline bone density, and high-sensitivity C-reactive protein (P < .001). In multiply adjusted models, the 12-month rate of change in bone density was +0.007% in the lowest tertile of FSH (FSH = 9 ± 7 IU/L, mean ± SD), -0.96% in the middle tertile (mean FSH = 41 ± 11 IU/L), and -2.2% in the highest tertile (mean FSH = 86 ± 19 IU/L), P for trend <.001.

conclusionsAmong premenopausal women with breast cancer treated with chemotherapy, baseline FSH levels are strongly associated with subsequent bone loss. Further studies are needed to establish the optimal timing of FSH measurement in relation to breast cancer treatment and to investigate potential strategies to prevent bone loss.

Indexed as

AdultAntineoplastic Combined Chemotherapy ProtocolsBone DensityBone Diseases, MetabolicBreast NeoplasmsChemotherapy, AdjuvantExercise TherapyFemaleFollicle Stimulating HormoneHumansMiddle AgedPremenopausePrimary Ovarian InsufficiencyPrognosisFollicle Stimulating Hormone

Identifiers

PMID26756114
PMCPMC4803178
OpenAlexW2235270575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.