ArticleInternational journal of oral science2015
Role of saliva proteinase 3 in dental caries.
Article in International journal of oral science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Exploring potential salivary biomarkers for dental caries: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Association of salivary proteins with dental caries in children with mixed dentition: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Pooled it
- Effects of salivary proteinase 3 and oxidative stress markers on secondary caries following pit-and-fissure sealants in patients with S-ECC.Annals of medicine and surgery (2012) · 2026Article
- Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel.Nature communications · 2025Article
- Salivary biomarkers in cancer detection and management.Acta biochimica Polonica · 2025Review
- Role of Salivary Protease Enzymatic Activity in Saliva of Children with and without Early Childhood Caries: A Randomized Clinical Trial.International journal of clinical pediatric dentistry · 2024Article
- Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population.Scientific reports · 2023Article
- Comparison of oral cavity protein abundance among caries-free and caries-affected individuals-a systematic review and meta-analysis.Frontiers in oral health · 2023Review
- Role of Salivary Biomarkers in Diagnosis and Detection of Dental Caries: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Salivary KLK5 and uPA are potential biomarkers for malignant transformation of OLK and OLP.Cancer biomarkers : section A of Disease markers · 2021Article
- Changes in salivary output after induction at high-altitude areas and its effects on dental caries among Indian Army troops.Medical journal, Armed Forces India · 2019Article
- [Analysis of salivary protease spectrum in chronic periodontitis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Article
- Saliva as a biomarker for dental caries: A systematic review.Journal of conservative dentistry : JCDReview
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salivary analysis can be used to assess the severity of caries. Of the known salivary proteins, a paucity of information exists concerning the role of proteinase 3 (PR3), a serine protease of the chymotrypsin family, in dental caries. Whole, unstimulated saliva was collected from children with varying degrees of active caries and tested using a Human Protease Array Kit and an enzyme-linked immunosorbent assay. A significantly decreased concentration of salivary PR3 was noted with increasing severity of dental caries (P<0.01); a positive correlation (r=0.87; P<0.01; Pearson's correlation analysis) was also observed between salivary pH and PR3 concentration. In an antibacterial test, a PR3 concentration of 250 ng·mL⁻¹ or higher significantly inhibited Streptococcus mutans UA159 growth after 12 h of incubation (P<0.05). These studies indicate that PR3 is a salivary factor associated with the severity of dental caries, as suggested by the negative relationship between salivary PR3 concentration and the severity of caries as well as the susceptibility of S. mutans to PR3.
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