ArticleIranian Red Crescent medical journal2015
Effect of Pentoxifylline Administration on an Experimental Rat Model of Femur Fracture Healing With Intramedullary Fixation.
Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of glucagon‑like peptide‑1 receptor agonists on fracture healing in a rat osteoporotic model.Experimental and therapeutic medicine · 2023Article
- The effect of two phosphodiesterase inhibitors on bone healing in mandibular fractures (animal study in rats).Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020Article
- Effects of Rhizoma Drynariae Cataplasm on Fracture Healing in a Rat Model of Osteoporosis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effects of pentoxifylline and alendronate on fracture healing in ovariectomy-induced osteoporosis in rats.Veterinary research forum : an international quarterly journal · 2019Article
- The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model.Laboratory animal research · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
backgroundGlobally, musculoskeletal injuries comprise a major public health problem that contributes to a large burden of disability and suffering. Pentoxifylline (PTX) has been originally used as a hemorheologic drug to treat intermittent claudication. Previous test tube and in vivo studies reported the beneficial effects of PTX on bony tissue.
objectivesThis study aims to evaluate the effects of different dosages of PTX on biomechanical properties that occur during the late phase of the fracture healing process following a complete femoral osteotomy in a rat model. We applied intramedullary pin fixation as the treatment of choice. MATERIALS AND
methodsThis experimental study was conducted at the Shahid Beheshti University of Medical Sciences, Tehran, Iran. We used the simple random technique to divide 35 female rats into five groups. Group 1 received intraperitoneal (i.p.) PTX (50 mg/kg, once daily) injections, starting 15 days before surgery, and group 2, group 3, and group 4 received 50 mg/kg, 100 mg/kg, and 200 mg/kg i.p. PTX injections, respectively, once daily after surgery. All animals across groups received treatment for six weeks (until sacrificed). Complete surgical transverse osteotomy was performed in the right femur of all rats. At six weeks after surgery, the femurs were subjected to a three-point bending test.
resultsDaily administration of 50 mg/kg PTX (groups 1 and 2) decreased the high stress load in repairing osteotomized femurs when compared with the control group. The highest dose of PTX (200 mg/kg) significantly increased the high stress load when compared with the control group (P = 0.030), group 1 (P = 0.023), group 2 (P = 0.008), and group 3 (P = 0.010), per the LSD findings.
conclusionsTreatment with 200 mg/kg PTX accelerated fracture healing when compared with the control group.
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