ArticleLaboratory animal research2015
Comparative analysis of growth characteristics of Sprague Dawley rats obtained from different sources.
Article in Laboratory animal research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies.PLoS genetics · 2022Pooled it
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- Intron polymorphism in Camk2d is associated with ventricular arrhythmias in normal adult Sprague-Dawley rats.Experimental animals · 2026Article
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- Paw Preference in Rats Across Tests, Strains, Sex, and Age: A PRISMA-Compliant Systematic Review and Meta-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Article
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- Updated Neuronal Numbers of the Rat Hippocampal Formation: Redesigning the Hippocampal Model.Hippocampus · 2026Article
- Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis).Frontiers in pharmacology · 2025Article
- Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats.The Journal of clinical investigation · 2024Article
- Development of a chronic compression spinal cord injury model in neonatal and adult rats.Animal models and experimental medicine · 2024Article
- The Future Exploring of Gut Microbiome-Immunity Interactions: From In Vivo/Vitro Models to In Silico Innovations.Microorganisms · 2024Review
- The first rodent behavioral study (1822) and the diffusion of human-bred albino rats and mice in the 19th century.Frontiers in psychology · 2024Review
- Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan's Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats.Drug design, development and therapy · 2024Article
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- Rodent models to study type 1 and type 2 diabetes induced human diabetic nephropathy.Molecular biology reports · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic background in animal models is an intrinsic research variable in biomedical research. Although inbred strains offer genetic uniformity, the outbred stocks, known for genetic variability are often used to develop animal models of human disease. The genetic variability is considered to be even higher when outbred stocks are obtained from different sources. In order to examine the degree of variability of an outbred stock obtained from various sources, Sprague Dawley (SD) rat lines obtained from two sources were evaluated for their growth characteristics. The SD rats from Charles River laboratories (CRL) and Harlan Laboratories (HAR) were monitored for weight gain from the age of 6 weeks to 24 weeks. Food intake was monitored between 13 and 24 weeks. Body composition, organ weights, tibial lengths and blood parameters were measured. There was no difference observed in food intake per 100 gram body weight at most of the time points. CRL rats showed higher body fat mass (49.6%), higher gross liver weights (22.2%), lower testicular weights (30.8%) and lower cholesterol levels (25.4%) than HAR rats. Phenotypic differences may be attributed to genetic heterogeneity of the SD outbred stock between the two sources and represent a significant research variable impacting studies especially related to metabolic diseases. Therefore, in order the minimize research variables for those studies where genetic diversity is not a basis for experimental design, the use of single source genetically uniform inbred animal models is highly recommended over the use of outbred stocks.
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