ReviewWorld journal of gastroenterology2016
Prediction of hepatocellular carcinoma biological behavior in patient selection for liver transplantation.
Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- The Predictive Role of [18F]FDG PET/CT in Early HCC Recurrence After Liver Transplantation.Cancers · 2026Article
- Review
- ctDNA as a novel and promising approach for cancer diagnosis: a focus on hepatocellular carcinoma.EXCLI journal · 2023Review
- Combined proteomic/transcriptomic signature of recurrence post-liver transplantation for hepatocellular carcinoma beyond Milan.Clinical proteomics · 2021Article
- Micronvasive behaviour of single small hepatocellular carcinoma: which treatment?Updates in surgery · 2021Article
- Article
- Liver Transplantation for Extended Criteria Hepatocellular Carcinoma Using Stable Response to Locoregional Therapy and Alpha-Fetoprotein as Selection Criteria.Visceral medicine · 2020Article
- Preoperative Prediction for Early Recurrence Can Be as Accurate as Postoperative Assessment in Single Hepatocellular Carcinoma Patients.Korean journal of radiology · 2020Article
- A novel machine learning algorithm to predict disease free survival after resection of hepatocellular carcinoma.Annals of translational medicine · 2020Article
- The association between genomic variations and histological grade in hepatocellular carcinoma.Translational cancer research · 2020Article
- Gadoxetic acid-enhanced MRI as a predictor of recurrence of HCC after liver transplantation.European radiology · 2020Article
- Diffusion-weighted imaging for identifying patients at high risk of tumor recurrence following liver transplantation.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
- Milan-out Criteria and Worse Intention-to-Treat Outcome Postliver Transplantation.Transplantation direct · 2019Article
- 3D MR Elastography of Hepatocellular Carcinomas as a Potential Biomarker for Predicting Tumor Recurrence.Journal of magnetic resonance imaging : JMRI · 2019Article
- Serological Risk Index Based on Alpha-Fetoprotein and C-Reactive Protein to Indicate Futile Liver Transplantation Among Patients with Advanced Hepatocellular Carcinoma.Digestive diseases and sciences · 2019Observational
- Role of pre-transplant 18F-FDG PET/CT in predicting hepatocellular carcinoma recurrence after liver transplantation.World journal of gastrointestinal oncology · 2018Review
- New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma.World journal of gastroenterology · 2018Review
- CombiningScientific reports · 2017Article
- Appropriate surgical therapy for patients with hepatocellular carcinoma beyond Milan criteria.Hepatobiliary surgery and nutrition · 2017Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphological criteria have always been considered the benchmark for selecting hepatocellular carcinoma (HCC) patients for liver transplantation (LT). These criteria, which are often inappropriate to express the tumor's biological behavior and aggressiveness, offer only a static view of the disease burden and are frequently unable to correctly stratify the tumor recurrence risk after LT. Alpha-fetoprotein (AFP) and its progression as well as AFP-mRNA, AFP-L3%, des-γ-carboxyprothrombin, inflammatory markers and other serological tests appear to be correlated with post-transplant outcomes. Several other markers for patient selection including functional imaging studies such as (18)F-FDG-PET imaging, histological evaluation of tumor grade, tissue-specific biomarkers, and molecular signatures have been outlined in the literature. HCC growth rate and response to pre-transplant therapies can further contribute to the transplant evaluation process of HCC patients. While AFP, its progression, and HCC response to pre-transplant therapy have already been used as a part of an integrated prognostic model for selecting patients, the utility of other markers in the transplant setting is still under investigation. This article intends to review the data in the literature concerning predictors that could be included in an integrated LT selection model and to evaluate the importance of biological aggressiveness in the evaluation process of these patients.
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