ArticleTransactions of the American Ophthalmological Society2015
Development of Selective Lamellar Keratoplasty within an Asian Corneal Transplant Program: The Singapore Corneal Transplant Study (An American Ophthalmological Society Thesis).
Article in Transactions of the American Ophthalmological Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Effects of Combined Cataract Surgery on Outcomes of Descemet's Membrane Endothelial Keratoplasty: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- National Survey on Corneal Transplantation in Japan.Cornea · 2026Article
- Deep learning-assisted widefield endothelial imaging in Descemet membrane endothelial keratoplasty.Frontiers in medicine · 2025Article
- Clinical outcomes in imported endothelium-in preloaded vs. surgeon-loaded DMEKs in Asian eyes.Frontiers in medicine · 2025Article
- Clinical outcomes of DMEK comparing endothelium-out injector and endothelium-in pull-through techniques in Asian eyes.Frontiers in medicine · 2025Article
- Demographic Profile and Clinical Characteristics of Fuchs Endothelial Corneal Dystrophy in Thai Patients: A Retrospective Cohort in a Tertiary Referral Center.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Changing indications for and trends of keratoplasty in a tertiary comprehensive hospital in northern part of China from 2002 to 2021: a 20-year review.BMC ophthalmology · 2024Article
- Pull-through insertion of EndoArt for complex eyes.American journal of ophthalmology case reports · 2023Article
- Corneal Endothelial-like Cells Derived from Induced Pluripotent Stem Cells for Cell Therapy.International journal of molecular sciences · 2023Review
- A long-term clinical outcome of Hoffmann pocket four-point scleral fixated intraocular lens implantation combined with penetrating keratoplasty - A single corneal surgeon's report.Indian journal of ophthalmology · 2023Article
- Mesenchymal Stem Cell Exosomes as Immunomodulatory Therapy for Corneal Scarring.International journal of molecular sciences · 2023Article
- An Overview of Corneal Transplantation in the Past Decade.Clinics and practice · 2023Review
- Big data in corneal diseases and cataract: Current applications and future directions.Frontiers in big data · 2023Review
- The outcome of 70/30 taco insertion through a 2.8 mm clear corneal incision in Descemet's stripping automated endothelial keratoplasty - A retrospective analysis.Indian journal of ophthalmology · 2022Article
- Evolution of corneal transplantation techniques and their indications in a French corneal transplant unit in 2000-2020.PloS one · 2022Article
- Machine Learning to Analyze Factors Associated With Ten-Year Graft Survival of Keratoplasty for Cornea Endothelial Disease.Frontiers in medicine · 2022Article
- Trends in surgical procedures and indications for corneal transplantation over 27 years in a tertiary hospital in Japan.Japanese journal of ophthalmology · 2021Article
- Management of Corneal Clouding in Patients with Mucopolysaccharidosis.Journal of clinical medicine · 2021Review
- Changing trends in corneal transplantation: a national review of current practices in the Republic of Ireland.Irish journal of medical science · 2021Review
- Evolution of therapies for the corneal endothelium: past, present and future approaches.The British journal of ophthalmology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate outcomes of anterior lamellar keratoplasty (ALK) and endothelial keratoplasty (EK) within the Singapore Corneal Transplant Study (SCTS), with the hypothesis that both ALK and EK are able to provide equivalent or improved clinical outcomes, compared to penetrating keratoplasty (PK), and to determine changing trends globally with other international databases.
methodsClinical data on all transplants performed was derived from our SCTS database, a prospective national keratoplasty registry, and clinical outcomes (graft survival, endothelial cell loss, complications, visual acuity) were compared between PK, ALK, and EK. Global trends on indications and forms of keratoplasty performed in 2011/2012 were obtained from national keratoplasty or eye banking registries, corneal/ophthalmological societies, national eye banks, and national ophthalmic institutions.
resultsGlobal rates of EK surgery vary widely, from 52% (Sweden) to 0% (South Africa), with higher adoption by industrialized countries. ALK adoption rates similarly vary from 28.7% (China) to 1.0% (Philippines). SCTS data show high adoption rates in Singapore: EK 44% and ALK 28%. Our surgical modifications to big-bubble deep anterior lamellar keratoplasty (DALK) surgery resulted in visual outcomes matching PK, and a low conversion to PK of 2.1%, whereas our evolving approaches to donor insertion in Descemet's stripping automated endothelial keratoplasty (DSAEK) show significant reduction in 1-year postoperative endothelial cell loss rates from 60% (folding), to 22% to 30% (Sheets Glide), to 15% (EndoGlide inserter).
conclusionImprovements in various forms of ALK and EK surgery can lead to better visual outcomes, longer graft survival, and reduced complications, as compared to PK. Global trends suggest adoption of these procedures at different rates.
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26755854PMC4692329W2418831382What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.