ArticleDevelopment (Cambridge, England)2016
Epithelial stratification and placode invagination are separable functions in early morphogenesis of the molar tooth.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Asymmetry of sonic hedgehog expression is necessary for early incisor tooth morphogenesis.Development (Cambridge, England) · 2026Article
- Whole tissue imaging of cellular boundaries at sub-micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- ECM-Syndecan-4-FAK signaling is associated with epithelial invagination and buccolingual asymmetry during mandibular molar development.Frontiers in physiology · 2026Article
- Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.PLoS genetics · 2024Article
- The oligodontia phenotype in a X-linked hypohidrotic ectodermal dysplasia patient with a novelHeliyon · 2024Article
- Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral.International journal of oral science · 2023Article
- Count Me in, Count Me out: Regulation of the Tooth Number via Three Directional Developmental Patterns.International journal of molecular sciences · 2023Review
- Tooth number abnormality: from bench to bedside.International journal of oral science · 2023Review
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- The effect of melatonin on the mouse ameloblast-lineage cell line ALCs.Scientific reports · 2022Article
- Hydrocoel morphogenesis forming the pentaradial body plan in a sea cucumber, Apostichopus japonicus.Scientific reports · 2022Article
- Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice.Stem cell research & therapy · 2022Article
- Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022Review
- Salivary Gland Development in Culture.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Eda controls the size of the enamel knot during incisor development.Frontiers in physiology · 2022Article
- Parallels in signaling between development and regeneration in ectodermal organs.Current topics in developmental biology · 2022Article
- DNCP induces the differentiation of induced pluripotent stem cells into odontoblasts by activating the Smad/p-Smad and p38/p-p38 signaling pathways.Experimental and therapeutic medicine · 2021Article
- Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development.Development (Cambridge, England) · 2021Article
- The initiation knot is a signaling center required for molar tooth development.Development (Cambridge, England) · 2021Article
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
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Authors and funding
5 authors.
Funding
Abstract
Ectodermal organs, which include teeth, hair follicles, mammary ducts, and glands such as sweat, mucous and sebaceous glands, are initiated in development as placodes, which are epithelial thickenings that invaginate and bud into the underlying mesenchyme. These placodes are stratified into a basal and several suprabasal layers of cells. The mechanisms driving stratification and invagination are poorly understood. Using the mouse molar tooth as a model for ectodermal organ morphogenesis, we show here that vertical, stratifying cell divisions are enriched in the forming placode and that stratification is cell division dependent. Using inhibitor and gain-of-function experiments, we show that FGF signalling is necessary and sufficient for stratification but not invagination as such. We show that, instead, Shh signalling is necessary for, and promotes, invagination once suprabasal tissue is generated. Shh-dependent suprabasal cell shape suggests convergent migration and intercalation, potentially accounting for post-stratification placode invagination to bud stage. We present a model in which FGF generates suprabasal tissue by asymmetric cell division, while Shh triggers cell rearrangement in this tissue to drive invagination all the way to bud formation.
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