ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults.Human brain mapping · 2023Trial
- Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.Brain sciences · 2025Article
- Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer's Disease Risk Beyond Hippocampal Atrophy.Psychiatry investigation · 2025Article
- Long-Term Blood Pressure Variability and Physical Performance in Older Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- Associations of Neurological Biomarkers in Serum With Gait Measures: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Ferroptosis of Microglia in Aging Human White Matter Injury.Annals of neurology · 2023Article
- Lower Myelin Content Is Associated With Lower Gait Speed in Cognitively Unimpaired Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Associations of physical function and body mass index with functional brain networks in community-dwelling older adults.Neurobiology of aging · 2023Observational
- Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin.Frontiers in neuroscience · 2023Article
- Gait in Cerebral Amyloid Angiopathy.Journal of the American Heart Association · 2022Article
- Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain aging.Journal of diabetes and its complications · 2022Article
- Association between white matter alterations on diffusion tensor imaging and incidence of frailty in older adults with cardiometabolic diseases.Frontiers in aging neuroscience · 2022Article
- Influences of dopaminergic system dysfunction on late-life depression.Molecular psychiatry · 2022Review
- The Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging.Journal of Alzheimer's disease : JAD · 2022Article
- The Correlation Between Modified Total Cerebral Small Vessel Disease Score and Gait and Balance Disorder in Middle-aged to Older Adults.Current neurovascular research · 2022Article
- Cerebral small vessel disease, cardiovascular risk factors, and future walking speed in old age: a population-based cohort study.BMC neurology · 2021Article
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Association Between Brain Volumes and Patterns of Physical Activity in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundWhite matter hyperintensities (WMH), a common marker of cerebral small vessel disease, and lower microstructural integrity of normal-appearing white matter are associated with slower gait. How these cerebral measures interact in relation to slower gait is unknown. We assessed whether microstructural integrity of normal-appearing white matter, measured by fractional anisotropy (FA), moderates the association of higher WMH with slower gait.
methodsWMH, FA, and gait speed were acquired for 265 community-dwelling older adults (average age = 82.9 years).
resultsThe inverse association between WMH and gait was robust to adjustment for age, gender, muscle strength, obesity, stroke, and hypertension (fully adjusted model: βs = -0.19, p = .001). The interaction between WMH and FA was significant; analyses stratified by FA showed that the inverse association between WMH and gait speed was significant only for those with low FA (FA < median, fully adjusted model: βs = -0.28, p = .001). Voxel-based results were similar for participants with FA less than median, there was an inverse association between gait speed and WMH which extended throughout the white matter (genu and body of corpus callosum, anterior limb of internal capsule, corona radiata, and superior longitudinal and fronto-occipital fasciculus). In contrast, for participants with FA ≥ median, the association was limited to the genu of corpus callosum, the cingulum, and the inferior longitudinal fasciculus.
conclusionsMicrostructural integrity is a moderating factor in the association between WMH and gait. Future studies should examine whether higher microstructural integrity represents a source of compensation in those with greater WMH burden to maintain function in late life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.