ArticleProceedings of the National Academy of Sciences of the United States of America2016
Decanalization of wing development accompanied the evolution of large wings in high-altitude Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- An ARVC-5 Drosophila knock-in model reveals new functions of Tmem43 in lipid homeostasis.Biology open · 2026Article
- The secrets of the extreme durability of odonata wings.Annals of the Entomological Society of America · 2025Article
- Adaptation to Nighttime Light via Gene Expression Regulation inEcology and evolution · 2025Article
- Recombinant inbred line panels inform the genetic architecture and interactions of adaptive traits in Drosophila melanogaster.G3 (Bethesda, Md.) · 2025Article
- Courtship song differs between African and European populations of Drosophila melanogaster and involves a strong effect locus.G3 (Bethesda, Md.) · 2025Article
- Wing vein abnormality analysis in honeybee (Apis mellifera L. 1758) populations from Iran.Scientific reports · 2024Article
- Rapid seasonal changes in phenotypes in a wild Drosophila population.Scientific reports · 2023Article
- Hybrid breakdown in male reproduction between recently diverged Drosophila melanogaster populations has a complex and variable genetic architecture.Evolution; international journal of organic evolution · 2023Article
- Long-term evolution of quantitative traits in the Drosophila melanogaster species subgroup.Genetica · 2022Article
- Gene Regulatory Evolution in Cold-Adapted Fly Populations Neutralizes Plasticity and May Undermine Genetic Canalization.Genome biology and evolution · 2022Article
- The evolution of larger size in high-altitude Drosophila melanogaster has a variable genetic architecture.G3 (Bethesda, Md.) · 2022Article
- Parallel and population-specific gene regulatory evolution in cold-adapted fly populations.Genetics · 2021Article
- Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.Molecular ecology · 2021Article
- Patterns of Genetic Diversity and Mating Systems in a Mass-Reared Black Soldier Fly Colony.Insects · 2021Article
- Sex and tissue-specific evolution of developmental plasticity inEcology and evolution · 2021Article
- Is Planting Trees Enough? The Effect of Different Types of Reforestation on the Offspring of Trypoxylon (Trypargilum) lactitarse (Hymenoptera: Crabronidae) in the Southern Amazon.Neotropical entomology · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Directional selection reduces developmental canalization against genetic and environmental perturbations in Drosophila wings.Evolution; international journal of organic evolution · 2018Article
- Parallel Evolution of Cold Tolerance within Drosophila melanogaster.Molecular biology and evolution · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In higher organisms, the phenotypic impacts of potentially harmful or beneficial mutations are often modulated by complex developmental networks. Stabilizing selection may favor the evolution of developmental canalization--that is, robustness despite perturbation--to insulate development against environmental and genetic variability. In contrast, directional selection acts to alter the developmental process, possibly undermining the molecular mechanisms that buffer a trait's development, but this scenario has not been shown in nature. Here, we examined the developmental consequences of size increase in highland Ethiopian Drosophila melanogaster. Ethiopian inbred strains exhibited much higher frequencies of wing abnormalities than lowland populations, consistent with an elevated susceptibility to the genetic perturbation of inbreeding. We then used mutagenesis to test whether Ethiopian wing development is, indeed, decanalized. Ethiopian strains were far more susceptible to this genetic disruption of development, yielding 26 times more novel wing abnormalities than lowland strains in F2 males. Wing size and developmental perturbability cosegregated in the offspring of between-population crosses, suggesting that genes conferring size differences had undermined developmental buffering mechanisms. Our findings represent the first observation, to our knowledge, of morphological evolution associated with decanalization in the same tissue, underscoring the sensitivity of development to adaptive change.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.