ReviewMolecular and cellular biology2016
Different Facets of Copy Number Changes: Permanent, Transient, and Adaptive.
Review in Molecular and cellular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic literature review assessing if genetic biomarkers are predictors for platinum-based chemotherapy response in ovarian cancer patients.European journal of clinical pharmacology · 2020Pooled it
- CNAttention: an attention-based deep multiple-instance method for uncovering copy number aberration signatures across cancers.Briefings in bioinformatics · 2026Article
- Analysis of clinicalAntimicrobial agents and chemotherapy · 2024Article
- Analysis of clinicalbioRxiv : the preprint server for biology · 2023Article
- Assessment of MYC and TERT copy number variations in lung cancer using digital PCR.BMC research notes · 2023Article
- Article
- Best Practices in Microbial Experimental Evolution: Using Reporters and Long-Read Sequencing to Identify Copy Number Variation in Experimental Evolution.Journal of molecular evolution · 2023Review
- A pan-cancer analysis of ABI3BP: a potential biomarker for prognosis and immunoinfiltration.Frontiers in oncology · 2023Article
- DNA repair as a shared hallmark in cancer and ageing.Molecular oncology · 2022Review
- The cancer puzzle: Welcome to organicism.Progress in biophysics and molecular biology · 2021Article
- Article
- Copy Number Variations of CEP63, FOSL2 and PAQR6 Serve as Novel Signatures for the Prognosis of Bladder Cancer.Frontiers in oncology · 2021Article
- Signatures of Discriminative Copy Number Aberrations in 31 Cancer Subtypes.Frontiers in genetics · 2021Article
- Identification and utilization of copy number information for correcting Hi-C contact map of cancer cell lines.BMC bioinformatics · 2020Article
- Integrative radiogenomics for virtual biopsy and treatment monitoring in ovarian cancer.Insights into imaging · 2020Review
- Multi-omic signatures identify pan-cancer classes of tumors beyond tissue of origin.Scientific reports · 2020Article
- Hierarchical discovery of large-scale and focal copy number alterations in low-coverage cancer genomes.BMC bioinformatics · 2020Article
- Over a century of cancer research: Inconvenient truths and promising leads.PLoS biology · 2020Article
- Immuno-genomic landscape of osteosarcoma.Nature communications · 2020Article
- Histone Lysine Methylation Dynamics ControlCancer discovery · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Chromosomal copy number changes are frequently associated with harmful consequences and are thought of as an underlying mechanism for the development of diseases. However, changes in copy number are observed during development and occur during normal biological processes. In this review, we highlight the causes and consequences of copy number changes in normal physiologic processes as well as cover their associations with cancer and acquired drug resistance. We discuss the permanent and transient nature of copy number gains and relate these observations to a new mechanism driving transient site-specific copy gains (TSSGs). Finally, we discuss implications of TSSGs in generating intratumoral heterogeneity and tumor evolution and how TSSGs can influence the therapeutic response in cancer.
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