ArticleJournal of psychopharmacology (Oxford, England)2016
The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task.
Article in Journal of psychopharmacology (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Abnormal prediction error processing in schizophrenia and depression.Human brain mapping · 2021Pooled it
- Separate neural representations of prediction error valence and surprise: Evidence from an fMRI meta-analysis.Human brain mapping · 2018Pooled it
- Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.The international journal of neuropsychopharmacology · 2018Trial
- Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning.Nature communications · 2022Article
- Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence.Scientific reports · 2021Article
- Patterns of Focal- and Large-Scale Synchronization in Cognitive Control and Inhibition: A Review.Frontiers in human neuroscience · 2020Review
- Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.Drug and alcohol dependence · 2018Article
- Modeling subjective relevance in schizophrenia and its relation to aberrant salience.PLoS computational biology · 2018Article
- Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.Neurobiology of aging · 2018Article
- Distinct neural processes support post-success and post-error slowing in the stop signal task.Neuroscience · 2017Article
- Response inhibition in Parkinson's disease: a meta-analysis of dopaminergic medication and disease duration effects.NPJ Parkinson's disease · 2017Review
- Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing.eNeuroArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
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Abstract
To adapt flexibly to a rapidly changing environment, humans must anticipate conflict and respond to surprising, unexpected events. To this end, the brain estimates upcoming conflict on the basis of prior experience and computes unsigned prediction error (UPE). Although much work implicates catecholamines in cognitive control, little is known about how pharmacological manipulation of catecholamines affects the neural processes underlying conflict anticipation and UPE computation. We addressed this issue by imaging 24 healthy young adults who received a 45 mg oral dose of methylphenidate (MPH) and 62 matched controls who did not receive MPH prior to performing the stop-signal task. We used a Bayesian Dynamic Belief Model to make trial-by-trial estimates of conflict and UPE during task performance. Replicating previous research, the control group showed anticipation-related activation in the presupplementary motor area and deactivation in the ventromedial prefrontal cortex and parahippocampal gyrus, as well as UPE-related activations in the dorsal anterior cingulate, insula, and inferior parietal lobule. In group comparison, MPH increased anticipation activity in the bilateral caudate head and decreased UPE activity in each of the aforementioned regions. These findings highlight distinct effects of catecholamines on the neural mechanisms underlying conflict anticipation and UPE, signals critical to learning and adaptive behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.