ArticleScientific reports2016
In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Development of a Radiotherapy-Induced Wound Model in Wistar Rats: Simulating Post-Radiation Skin and Soft Tissue Complications for Therapeutic Evaluation.Biomedicines · 2026Article
- Establishing an animal model for post-inflammatory hyperpigmentation following fractional COLasers in medical science · 2025Article
- Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis.Scientific reports · 2024Article
- Longitudinal Neuropathological Consequences of Extracranial Radiation Therapy in Mice.International journal of molecular sciences · 2024Article
- An Experimental Model of Proton-Beam-Induced Radiation Dermatitis In Vivo.International journal of molecular sciences · 2023Article
- Effects of Radiation-Induced Skin Injury on Hyaluronan Degradation and Its Underlying Mechanisms.Molecules (Basel, Switzerland) · 2023Article
- The Potential of Photoacoustic Imaging in Radiation Oncology.Frontiers in oncology · 2022Article
- Preclinical modeling of low energy X-rays radiological burn: Dosimetry study by monte carlo simulations and EPR spectroscopy.Frontiers in physiology · 2022Article
- Acute Radiation Dermatitis Evaluation with Reflectance Confocal Microscopy: A Prospective Study.Diagnostics (Basel, Switzerland) · 2021Article
- Longitudinal MRI study after carbon ion and photon irradiation: shorter latency time for myelopathy is not associated with differential morphological changes.Radiation oncology (London, England) · 2021Article
- Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography.Biomedical optics express · 2020Article
- Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP.PloS one · 2020Article
- Optical coherence tomography-guided dynamic focusing for combined optical and mechanical scanning multimodal photoacoustic microscopy.Journal of biomedical optics · 2019Article
- Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation.Cancers · 2019Article
- Integrated multimodal photoacoustic microscopy with OCT- guided dynamic focusing.Biomedical optics express · 2019Article
- Impaired Skin Barrier Due to Sebaceous Gland Atrophy in the Latent Stage of Radiation-Induced Skin Injury: Application of Non-Invasive Diagnostic Methods.International journal of molecular sciences · 2018Article
- Noninvasive assessment of cutaneous alterations in mice exposed to whole body gamma irradiation using optical imaging techniques.Lasers in medical science · 2017Article
- Visualization of laser tattoo removal treatment effects in a mouse model by two-photon microscopy.Biomedical optics express · 2017Article
- Early biomarker for radiation-induced wounds: day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionizing radiation (IR) injury is tissue damage caused by high energy electromagnetic waves such as X-ray and gamma ray. Diagnosis and treatment of IR injury are difficult due to its characteristics of clinically latent post-irradiation periods and the following successive and unpredictable inflammatory bursts. Skin is one of the many sensitive organs to IR and bears local injury upon exposure. Early-stage diagnosis of IR skin injury is essential in order to maximize treatment efficiency and to prevent the aggravation of IR injury. In this study, early-stage changes of the IR injured skin at the cellular level were characterized in an in vivo mouse model by two-photon microscopy (TPM). Various IR doses were applied to the mouse hind limbs and the injured skin regions were imaged daily for 6 days after IR irradiation. Changes in the morphology and distribution of the epidermal cells and damage of the sebaceous glands were observed before clinical symptoms. These results showed that TPM is sensitive to early-stage changes of IR skin injury and may be useful for its diagnosis.
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