ArticleCancer2016
Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study.
Article in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quality of life among people with eye cancer: a systematic review from 2012 to 2022.Health and quality of life outcomes · 2024Pooled it
- Psychosocial outcomes and quality of life among school-age survivors of retinoblastoma.Pediatric blood & cancer · 2023Article
- Ocular survival after intra-arterial chemotherapy for retinoblastoma improves with accrual of experience and programmatic evolution.Pediatric blood & cancer · 2023Article
- Long-Term Outcomes in Survivors of Childhood Cancer: A 30-Year Experience From India.JCO global oncology · 2022Article
- Successful Treatment of Late Isolated Bone Metastasis in a Patient with Bilateral Retinoblastoma Using an Unconventional Method.Ocular oncology and pathology · 2021Article
- General cancer screening practices among adult survivors of retinoblastoma: Results from the Retinoblastoma Survivor Study.Pediatric blood & cancer · 2021Article
- The Dutch LATER physical outcomes set for self-reported data in survivors of childhood cancer.Journal of cancer survivorship : research and practice · 2020Article
- Impact of enucleation on adult retinoblastoma survivors' quality of life: A qualitative study of survivors' perspectives.Palliative & supportive care · 2020Article
- Vision-Targeted Health-Related Quality of Life in Adult Survivors of Retinoblastoma.JAMA ophthalmology · 2018Article
- Growth patterns of survivors of retinoblastoma treated with ophthalmic artery chemosurgery.PloS one · 2018Article
- Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group.American journal of ophthalmology · 2017Article
- Health-Related Quality of Life in Adolescent and Young Adult Retinoblastoma Survivors.Journal of pediatric hematology/oncology nursingArticle
- Long-term follow-up of retinoblastoma survivors: Experience from India.South Asian journal of cancerArticle
- Retinoblastoma: Making a Difference Together.Asia-Pacific journal of oncology nursingArticle
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Abstract
backgroundLimited data are available regarding long-term morbidity in adult survivors of retinoblastoma (Rb).
methodsThe Retinoblastoma Survivor Study is a retrospective cohort of adult survivors of Rb diagnosed between 1932 and 1994. Participants completed a comprehensive questionnaire adapted from the Childhood Cancer Survivor Study surveys. Chronic conditions were classified using the National Cancer Institute's Common Terminology Criteria for Adverse Events (version 4.03). Multivariate Poisson regression was used to compare survivors of Rb with 2377 non-Rb controls, consisting of the Childhood Cancer Survivor Study sibling cohort and survivors with bilateral versus unilateral disease.
resultsSurvivors of Rb (53.6% with bilateral disease) and non-Rb controls had a mean age of 43.3 years (standard deviation, 11 years) and 37.6 years (SD, 8.6 years), respectively, at the time of study enrollment. At a median follow-up of 42 years (range, 15-75 years), 86.6% of survivors of Rb had at least 1 condition and 71.1% had a severe/life-threatening (grade 3-4) condition. The adjusted relative risk (RR) of a chronic condition in survivors compared with non-Rb controls was 1.4 (95% confidence interval [95% CI], 1.3-1.4; P<.01); for a grade 3 to 4 condition, the RR was 7.6 (95% CI, 6.4-8.9; P<.01). Survivors were at an excess risk regardless of laterality. After stratifying by laterality and excluding ocular conditions and second malignant neoplasms (SMNs), only those with bilateral disease were found to be at an increased risk of any nonocular, non-SMN condition (RR, 1.2; 95% CI, 1.1-1.2) and for grade 3 to 4 nonocular, non-SMN conditions (RR, 1.7; 95% CI, 1.2-2.5).
conclusionsSurvivors of Rb have an increased risk of chronic conditions compared with non-Rb controls. After excluding ocular conditions and SMNs, this excess risk was found to persist only for those with bilateral disease. Cancer 2016;122:773-781. © 2016 American Cancer Society.
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