ArticleObesity surgery2016
Continuous Glucose Monitoring After Gastric Bypass to Evaluate the Glucose Variability After a Low-Carbohydrate Diet and to Determine Hypoglycemia.
Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- The Value of Liquid and Solid Mixed Meal Tolerance Tests in Diagnosis of Postprandial Reactive Hypoglycaemic Syndrome After Gastric Bypass Surgery.Obesity surgery · 2025Article
- Continuous Glucose Monitoring Captures Glycemic Variability After Roux-en-Y Gastric Bypass in Patients with and Without Type 2 Diabetes Mellitus: A Prospective Cohort Study.Obesity surgery · 2024Article
- Society for Endocrinology guidelines for the diagnosis and management of post-bariatric hypoglycaemia.Endocrine connections · 2024Review
- Use of Continuous Glucose Monitoring in Patients Following Bariatric Surgery: A Scoping Review.Obesity surgery · 2023Article
- Acute Effects of Sleeve Gastrectomy on Glucose Variability, Glucose Metabolism, and Ghrelin Response.Obesity surgery · 2021Article
- Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program.Scientific reports · 2021Observational
- Glycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB).The Journal of clinical endocrinology and metabolism · 2021Article
- Intermittent Use of Continuous Glucose Monitoring: Expanding the Clinical Value of CGM.Journal of diabetes science and technology · 2021Article
- Patient involvement to inform the design of a clinical trial in postbariatric hypoglycaemia.BMC medical research methodology · 2020Article
- Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery.Chinese medical journal · 2020Review
- Use of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and management.Scientific reports · 2020Article
- Management of Diabetes in Patients Undergoing Bariatric Surgery.Current diabetes reports · 2019Review
- Continuous glucose monitoring in the management of patients after gastric bypassEndocrinology, diabetes & metabolism case reports · 2019Article
- Comparison of Meal Pattern and Postprandial Glucose Response in Duodenal Switch and Gastric Bypass Patients.Obesity surgery · 2019Article
- Role of Continuous Glucose Monitoring in Clinical Trials: Recommendations on Reporting.Diabetes technology & therapeutics · 2017Review
- Longitudinal Evaluation of Glucose Profile and Obesity Using Continuous Glucose Monitoring, Bioelectrical Impedance Analysis, and Computed Tomography Fat Scan in a Patient Who Achieved Diabetes Remission After Laparoscopic Sleeve Gastrectomy Duodenojejunal Bypass.AACE endocrinology and diabetesArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoux-en-Y gastric bypass (RYGB) alters glucose metabolism and can cause postprandial hypoglycemia. Continuous glucose monitoring (CGM) has been proposed as an evaluation tool in hypoglycemic RYGB individuals. The objective of this study is to investigate the use of CGM in clinical decision-making including diagnosing hypoglycemia and evaluating treatment effects. Furthermore, we aim to assess its accuracy in RYGB-operated individuals.
methodsThirteen RYGB individuals with symptomatic hypoglycemia and 13 asymptomatic RYGB individuals underwent CGM for 5 days. During this period, a mixed-meal test with concomitant plasma glucose (PG) measurements was performed. Furthermore, the RYGB individuals followed a low-carbohydrate diet (LCD) for 1 day and maintained their ordinary diet (OD) for the rest of the period.
resultsLCD reduced the CGM-determined glycemic variability of the mean interstitial fluid glucose (IFG) significantly compared to OD (p < 0.0001). Receiver operating characteristic analysis confirmed that low blood glucose index (e.g., the frequency and amplitude of hypoglycemic events) is the most reliable parameter related to the development of symptomatic hypoglycemia, with a sensitivity of 0.91 (confidence interval [CI] 0.59; 1.00) and a specificity of 0.77 (CI 0.46; 0.95). However, CGM, measuring the IFG in the subcutaneous adipose tissue, overestimated the minimum glucose levels by 1.1 ± 0.9 mmol/l compared with PG.
conclusionsCGM was a good method for demonstrating increased glycemic variability among RYGB individuals and for displaying dietary effects on reducing this glycemic variability, including hypoglycemic events. In RYGB individuals, CGM-measured IFG overestimated the real glucose value by about 1 mmol/l in the hypoglycemic range. This should be taken into consideration if CGM is used to diagnose hypoglycemia after RYGB.
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