Evidence map›Paper›PMID 26755082›Full record

ArticleThe journal of sexual medicine2016

Low-energy Shock Wave Therapy Ameliorates Erectile Dysfunction in a Pelvic Neurovascular Injuries Rat Model.

Huixi Li, Melanie P Matheu, Fionna Sun, Lin Wang, Melissa T Sanford, Hongxiu Ning, Lia Banie, Yung-Chin Lee, Zhongcheng Xin, Yinglu Guo and 2 more

Erratum issued Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in The journal of sexual medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07592533 (A Single Arm Study of EXtracorporeal Shockwave Therapy for mAnagement of ereCtile dYsfunction), which is not on this map. Cited by 83 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 3 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07592533 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Single Arm Study of EXtracorporeal Shockwave Therapy for mAnagement of ereCtile dYsfunction (EXSTACY Study)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2027Enrolled157ConditionsErectile DysfunctionArmsShockwave therapy
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.

  1. Pooled it
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  6. Extracorporeal shockwave therapy in tissue repair and regeneration.Wiener medizinische Wochenschrift (1946) · 2026
    Review
  7. Article
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  9. Peripheral nerve repair: innovations and future directions.Journal of translational medicine · 2026
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Huixi LiKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA; Department of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, P.R. China.
Melanie P MatheuDiabetes Center, University of California, San Francisco, CA, USA.
Fionna SunKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Lin WangKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA; Department of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, P.R. China.
Melissa T SanfordKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Hongxiu NingKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Lia BanieKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Yung-Chin LeeKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA; Department of Urology, Kaohsiung Medical University Hospital, Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Zhongcheng XinDepartment of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, P.R. China.
Yinglu GuoDepartment of Urology, Peking University First Hospital and the Institute of Urology, Peking University, Beijing, P.R. China.
Guiting LinKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Tom F LueKnuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA. Electronic address: tlue@urology.ucsf.edu.
University of California, San Francisco · USUrology San Antonio · USPeking University First Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionErectile dysfunction (ED) caused by pelvic injuries is a common complication of civil and battlefield trauma with multiple neurovascular factors involved, and no effective therapeutic approach is available.

aimsTo test the effect and mechanisms of low-energy shock wave (LESW) therapy in a rat ED model induced by pelvic neurovascular injuries.

methodsThirty-two male Sprague-Dawley rats injected with 5-ethynyl-2'-deoxyuridine (EdU) at newborn were divided into 4 groups: sham surgery (Sham), pelvic neurovascular injury by bilateral cavernous nerve injury and internal pudendal bundle injury (PVNI), PVNI treated with LESW at low energy (Low), and PVNI treated with LESW at high energy (High). After LESW treatment, rats underwent erectile function measurement and the tissues were harvested for histologic and molecular study. To examine the effect of LESW on Schwann cells, in vitro studies were conducted. MAIN OUTCOME MEASUREMENTS: The intracavernous pressure (ICP) measurement, histological examination, and Western blot (WB) were conducted. Cell cycle, Schwann cell activation-related markers were examined in in vitro experiments.

resultsLESW treatment improves erectile function in a rat model of pelvic neurovascular injury by leading to angiogenesis, tissue restoration, and nerve generation with more endogenous EdU(+) progenitor cells recruited to the damaged area and activation of Schwann cells. LESW facilitates more complete re-innervation of penile tissue with regeneration of neuronal nitric oxide synthase (nNOS)-positive nerves from the MPG to the penis. In vitro experiments demonstrated that LESW has a direct effect on Schwann cell proliferation. Schwann cell activation-related markers including p-Erk1/2 and p75 were upregulated after LESW treatment.

conclusionLESW-induced endogenous progenitor cell recruitment and Schwann cell activation coincides with angiogenesis, tissue, and nerve generation in a rat model of pelvic neurovascular injuries.

Indexed as

Ultrasonic TherapyAnimalsBlotting, WesternDeoxyuridineDisease Models, AnimalErectile DysfunctionMaleNitric Oxide Synthase Type IPelvisPenile ErectionPenisProstatectomyRatsRats, Sprague-DawleySchwann CellsTrauma, Nervous System5-ethynyl-2'-deoxyuridineDeoxyuridineNitric Oxide Synthase Type IAngiogenesisEndogenous Progenitor CellsErectile DysfunctionLow Energy Shock WaveNerve RegenerationSchwann Cells

Identifiers

PMID26755082
OpenAlexW2222349568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.