ArticleBrain structure & function2016
The white matter query language: a novel approach for describing human white matter anatomy.
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of automated methods to perform white matter tract segmentation.Frontiers in neuroscience · 2024Pooled it
- Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge.Journal of magnetic resonance imaging : JMRI · 2020Pooled it
- Multi-compartment Myelin Streamline Decomposition reveals tract-specific and global brain network myelination in Multiple Sclerosis.Neuroimage. Reports · 2026Article
- Altered Cortical Gyrification Is Associated with Cortical and White Matter Microstructure in Individuals with Early Psychosis: A Multimodal Neuroimaging Study.Schizophrenia bulletin · 2026Article
- Benchmarking Generalizability in Deep Learning-Based White Matter Tract Segmentation.bioRxiv : the preprint server for biology · 2026Article
- Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc.bioRxiv : the preprint server for biology · 2026Article
- Deep learning-based Desikan-Killiany parcellation of the brain using diffusion MRI.Scientific reports · 2026Article
- Evaluating Unimodal and Multimodal Tracking Strategies for the Reconstruction of Language-related White Matter Tracts.Clinical neuroradiology · 2026Article
- Anatomically constrained and curated cerebellar tractography (ACCURAT): an open framework and a pathway-specific neuroanatomical reference.bioRxiv : the preprint server for biology · 2026Article
- Manifold lateralisation and variability in the language connectome at 7T.Research square · 2026Article
- Mouse white matter matters: cortical origins and spatial organization of mouse white matter tracts.Brain structure & function · 2026Article
- Bridging Continuous and Discrete Models of the Anterior Temporal Lobe via Cortical Gradients.Research square · 2026Article
- Detailed Delineation of the Fetal Brain in Diffusion MRI via Multi-Task Learning.IEEE transactions on medical imaging · 2026Article
- Study of sex differences in the whole brain white matter using diffusion MRI tractography and suprathreshold fiber cluster statistics.NeuroImage. Clinical · 2026Article
- Article
- Study of Sex Differences in the Whole Brain White Matter Using Diffusion MRI Tractography and Suprathreshold Fiber Cluster Statistics.bioRxiv : the preprint server for biology · 2025Article
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Atlas-based templates vs. subject-specific tractography: resolving the debate.Brain structure & function · 2025Review
- A software ecosystem for brain tractometry processing, analysis, and insight.PLoS computational biology · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We have developed a novel method to describe human white matter anatomy using an approach that is both intuitive and simple to use, and which automatically extracts white matter tracts from diffusion MRI volumes. Further, our method simplifies the quantification and statistical analysis of white matter tracts on large diffusion MRI databases. This work reflects the careful syntactical definition of major white matter fiber tracts in the human brain based on a neuroanatomist's expert knowledge. The framework is based on a novel query language with a near-to-English textual syntax. This query language makes it possible to construct a dictionary of anatomical definitions that describe white matter tracts. The definitions include adjacent gray and white matter regions, and rules for spatial relations. This novel method makes it possible to automatically label white matter anatomy across subjects. After describing this method, we provide an example of its implementation where we encode anatomical knowledge in human white matter for ten association and 15 projection tracts per hemisphere, along with seven commissural tracts. Importantly, this novel method is comparable in accuracy to manual labeling. Finally, we present results applying this method to create a white matter atlas from 77 healthy subjects, and we use this atlas in a small proof-of-concept study to detect changes in association tracts that characterize schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.