Evidence map›Paper›PMID 26754754›Full record

ReviewIntensive care medicine2016

Organ donation in adults: a critical care perspective.

Giuseppe Citerio, Marcelo Cypel, Geoff J Dobb, Beatriz Dominguez-Gil, Jennifer A Frontera, David M Greer, Alex R Manara, Sam D Shemie, Martin Smith, Franco Valenza and 1 more

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04131140 (Differences Across ICUs in Organ Donation After Brain Death), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04131140 completednot on this map

Differences Across ICUs in Organ Donation After Brain Death: A Nationwide Study of Relationship With Variation in End-of-life Decisions

Typeobservational_patient_registrySponsorSwedish Intensive Care RegistryRan2014 to 2018Enrolled12,072ConditionsDecision Making, Terminal Illness, Tissue and Organ Procurement
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Anticipated Organ Donation Approach Increases the Number of Organ Donors.Turkish journal of anaesthesiology and reanimation · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Practice and challenges for organ donation after medical assistance in dying: A scoping review including the results of the first international roundtable in 2021.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  15. Article
  16. Donation after circulatory death and lung transplantation.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022
    Review
  17. Article
  18. Article
  19. NormothermicFrontiers in cell and developmental biology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 6 countries.

Giuseppe CiterioSchool of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy. giuseppe.citerio@unimib.it.ORCID http://orcid.org/0000-0002-5374-3161
Marcelo CypelDivision of Thoracic Surgery, University of Toronto, Toronto, ON, M5G 2C4, Canada.
Geoff J DobbIntensive Care Unit, Royal Perth Hospital, Perth, WA, Australia.
Beatriz Dominguez-GilOrganización Nacional de Trasplantes, C/Sinesio Delgado 6, Pabellón 3, 28029, Madrid, Spain.
Jennifer A FronteraCerebrovascular Center of the Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
David M GreerDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Alex R ManaraThe Intensive Care Unit, Southmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK.
Sam D ShemieDivision of Critical Care, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
Martin SmithDepartment of Neurocritical Care, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK.
Franco ValenzaDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Eelco F M WijdicksDivision of Critical Care Neurology, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Azienda Ospedaliera San Gerardo · ITCleveland Clinic · USMayo Clinic · USMontreal Children's Hospital · CANorth Bristol NHS Trust · GBOrganización Nacional de Trasplantes · ESRoyal London Hospital · GBThe University of Western Australia · AUUniversity of Milan · ITUniversity of Toronto · CAYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe shortage of organs for transplantation is an important medical and societal problem because transplantation is often the best therapeutic option for end-stage organ failure.

methodsWe review the potential deceased organ donation pathways in adult ICU practice, i.e. donation after brain death (DBD) and controlled donation after circulatory death (cDCD), which follows the planned withdrawal of life-sustaining treatments (WLST) and subsequent confirmation of death using cardiorespiratory criteria.

resultsStrategies in the ICU to increase the number of organs available for transplantation are discussed. These include timely identification of the potential organ donor, optimization of the brain-dead donor by aggressive management of the physiological consequence of brain death, implementation of cDCD protocols, and the potential for ex vivo perfusion techniques.

conclusionsOrgan donation should be offered as a routine component of the end-of-life care plan of every patient dying in the ICU where appropriate, and intensivists are the key professional in this process.

Indexed as

Brain DeathHeart ArrestIntensive Care UnitsTissue and Organ ProcurementAdultHumansWithholding TreatmentBrain deathDonation after brain deathDonation after circulatory deathIntensive careOrgan donation

Identifiers

PMID26754754
OpenAlexW2233289629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.