Trial reportJournal of assisted reproduction and genetics2016
Intracytoplasmic morphologically selected sperm injection (IMSI) does not improve outcome in patients with two successive IVF-ICSI failures.
Trial report in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- IMSI-Guidelines for Sperm Quality Assessment.Diagnostics (Basel, Switzerland) · 2022Guideline
- Impact of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) on Birth Defects: A Systematic Review and Meta-Analysis.JBRA assisted reproduction · 2021Pooled it
- Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Regular (ICSI) versus ultra-high magnification (IMSI) sperm selection for assisted reproduction.The Cochrane database of systematic reviews · 2020Pooled it
- Trial
- Association between early embryo morphokinetics plus transcript levels of sperm apoptotic genes and clinical outcomes in IMSI and ICSI cycles of male factor patients.Journal of assisted reproduction and genetics · 2020Trial
- The efficacy of ionomycin - induced artificial oocyte activation in preventing fertilization failure in an ICSI cycle: an eight - year retrospective study.Journal of ovarian research · 2025Article
- Microplastic Contamination of Human Sperm before In Vitro Fertilization Warrants Attention for Early Life Exposure Risks.Environment & health (Washington, D.C.) · 2025Article
- Article
- Article
- Semantic segmentation of human oocyte images using deep neural networks.Biomedical engineering online · 2021Article
- Novel Techniques of Sperm Selection for Improving IVF and ICSI Outcomes.Frontiers in cell and developmental biology · 2019Review
- Magnetic-activated cell sorting of non-apoptotic spermatozoa improves the quality of embryos according to female age: a prospective sibling oocyte study.Journal of assisted reproduction and genetics · 2018Article
- Intracytoplasmic sperm injection: state of the art in humans.Reproduction (Cambridge, England) · 2017Review
- Comment on: "Intracytoplasmic morphologically selected sperm injection (IMSI) does not improve outcome in patients with two successive IVF-ICSI failures" by Gatimel et al.Journal of assisted reproduction and genetics · 2016Article
- Are there optimal numbers of oocytes, spermatozoa and embryos in assisted reproduction?JBRA assisted reproduction · 2016Review
- The Beneficial Role of Intra Cytoplasmic Morphologically Selected Sperm Injection (IMSI) in Assisted Reproduction.Journal of reproduction & infertilityReview
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAssessment of sperm morphology has been reconsidered since 2001 with the development of motile sperm organelle morphology examination (MSOME). This observation technique that combines high magnification microscopy and the Nomarski interference contrast makes it possible to select spermatozoa with as few vacuoles as possible before microinjection into the oocyte (intracytoplasmic morphologically selected sperm injection, IMSI). More than 10 years after the development of IMSI, the indications of the IMSI technique and its ability to increase pregnancy and/or birthrates (compared with conventional ICSI) are still subject to debate. We aimed to better define the interest of IMSI in the third attempt.
methodsWe assessed the benefit of IMSI by carrying out a retrospective comparative study between IMSI and conventional ICSI during a third ART attempt. Two hundred sixteen couples with two previous ICSI failures were studied between February 2010 and June 2014.
resultsIMSI did not significantly improve the clinical outcomes compared with ICSI, either for implantation (12 vs 10%), clinical pregnancy (23 vs 21%), or live birth rates (20 vs 19%).
conclusionThis study provides supplementary arguments for not achieving IMSI procedure in the third attempt after two previous ICSI failures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.