ArticleJournal of general internal medicine2016
Association of Opioids with Falls, Fractures, and Physical Performance among Older Men with Persistent Musculoskeletal Pain.
Article in Journal of general internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Association between opium consumption and sarcopenia in middle-aged and older adults: findings from the Fasa Adults Cohort Study (FACS).Scientific reports · 2026Article
- Association of morphine vs. fentanyl prescription dispensation with adverse clinical outcomes.Frontiers in pharmacology · 2025Article
- Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China.Frontiers in public health · 2025Article
- A Longitudinal Decline in Walking Speed Is Linked with Coexisting Hypertension and Arthritis in Community-Dwelling Older Adults.Journal of clinical medicine · 2024Article
- Opioid Use and Driving Performance.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Review
- Unintended Consequences of Opioid Regulations in Older Adults with Multiple Chronic Conditions.The Gerontologist · 2020Article
- Does early physical therapy intervention reduce opioid burden and improve functionality in the management of chronic lower back pain?The mental health clinician · 2020Article
- Are we missing opioid-related deaths among people with HIV?Drug and alcohol dependence · 2020Article
- Multimorbidity and Opioid Prescribing in Hospitalized Older Adults.Journal of palliative medicine · 2020Article
- Effects of Ohio's opioid prescribing limit for the geriatric minimally injured trauma patient.American journal of surgery · 2020Article
- Impact of Function Focused Care and Physical Activity on Falls in Assisted Living Residents.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2020Article
- Opioid Prescribing in the Elderly: A Systematic Review.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2020Review
- Frailty predicts fractures among women with and at-risk for HIV.AIDS (London, England) · 2019Article
- Recent opioid use and fall-related injury among older patients with trauma.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Observational
- Effects of Mantra Meditation versus Music Listening on Knee Pain, Function, and Related Outcomes in Older Adults with Knee Osteoarthritis: An Exploratory Randomized Clinical Trial (RCT).Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Evaluating the Risks of Opioid Use for Chronic Pain: Moving Beyond Overdose.Journal of general internal medicine · 2016Article
- Observational Study of the Safety of Chiropractic vs Medical Care Among Older Adults With Neck Pain.Journal of manipulative and physiological therapeuticsObservational
- Resilient to Pain: A Model of How Yoga May Decrease Interference Among People Experiencing Chronic Pain.Explore (New York, N.Y.)Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundAlthough older adults are disproportionately affected by painful musculoskeletal conditions and receive more opioid analgesics than persons in other age groups, insufficient evidence is available regarding opioid harms in this age group.
objectiveTo examine longitudinal relationships between opioid use and falls, clinical fractures, and changes in physical performance. We hypothesized that opioid use would be associated with greater risks of falling and incident clinical fractures and greater declines in physical performance.
designWe analyzed data from the Osteoporotic Fractures in Men Study (MrOS), a large prospective longitudinal cohort study. Participants completed baseline visits from 2000 to 2002 and were followed for 9.1 (SD 4.0) years.
participantsMrOS enrolled 5994 community-dwelling men ≥ 65 years of age. The present study included 2902 participants with back, hip, or knee pain most or all of the time at baseline. MAIN MEASURES: The exposure of interest was opioid use, defined at each visit as participant-reported daily or near-daily use of any opioid-containing analgesic. Among patients, 309 (13.4 %) reported opioid use at one or more visits. Participants were queried every 4 months about falls and fractures. Physical performance scores were derived from tests of grip strength, chair stands, gait speed, and dynamic balance. KEY
resultsIn the main analysis, the adjusted risk of falling did not differ significantly between opioid use and non-use groups (RR 1.10, 95% CI 0.99, 1.24). Similarly, adjusted rates of incident clinical fracture did not differ between groups (HR 1.13, 95% CI 0.94, 1.36). Physical performance was worse at baseline for the opioid use group, but annualized change in physical performance scores did not differ between groups (-0.022, 95% CI -0.138, 0.093).
conclusionsAdditional research is needed to determine whether opioid use is a marker of risk or a cause of falls, fractures, and progressive impairment among older adults with persistent pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.