ArticleThe Journal of cell biology2016
Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly.
Article in The Journal of cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 110 citations in OpenAlex.
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- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster.Developmental cell · 2025Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.Molecular biology of the cell · 2024Article
- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues.bioRxiv : the preprint server for biology · 2023Article
- Direct investigation of cell contraction signal networks by light-based perturbation methods.Pflugers Archiv : European journal of physiology · 2023Review
- Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity.Cell adhesion & migration · 2023Article
- The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023Review
- Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction.The Journal of cell biology · 2022Article
- Cellular dynamics of EMT: lessons from live in vivo imaging of embryonic development.Cell communication and signaling : CCS · 2021Review
- Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation.PLoS computational biology · 2021Article
- Article
- Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature.Development (Cambridge, England) · 2021Article
- Live Imaging of Epithelial-Mesenchymal Transition in Mesoderm Cells of Gastrulating Drosophila Embryos.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium ofeLife · 2020Article
- Cell intercalation in a simple epithelium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Orchestrating morphogenesis: building the body plan by cell shape changes and movements.Development (Cambridge, England) · 2020Review
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Although Snail is essential for disassembly of adherens junctions during epithelial-mesenchymal transitions (EMTs), loss of adherens junctions in Drosophila melanogaster gastrula is delayed until mesoderm is internalized, despite the early expression of Snail in that primordium. By combining live imaging and quantitative image analysis, we track the behavior of E-cadherin-rich junction clusters, demonstrating that in the early stages of gastrulation most subapical clusters in mesoderm not only persist, but move apically and enhance in density and total intensity. All three phenomena depend on myosin II and are temporally correlated with the pulses of actomyosin accumulation that drive initial cell shape changes during gastrulation. When contractile myosin is absent, the normal Snail expression in mesoderm, or ectopic Snail expression in ectoderm, is sufficient to drive early disassembly of junctions. In both cases, junctional disassembly can be blocked by simultaneous induction of myosin contractility. Our findings provide in vivo evidence for mechanosensitivity of cell-cell junctions and imply that myosin-mediated tension can prevent Snail-driven EMT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.