Evidence map›Paper›PMID 26754616›Full record

ArticleParasites & vectors2016

Development and usefulness of an immunochromatographic device to detect antibodies for rapid diagnosis of human gnathostomiasis.

Penchom Janwan, Pewpan M Intapan, Hiroshi Yamasaki, Rutchanee Rodpai, Porntip Laummaunwai, Tongjit Thanchomnang, Oranuch Sanpool, Kaoru Kobayashi, Katsuyoshi Takayama, Yukuharu Kobayashi and 1 more

Abstract read
In one paragraph

Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
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  9. Article
  10. Evaluation of Rapid IgG4 Test for Diagnosis of Gnathostomiasis.The Korean journal of parasitology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Penchom JanwanResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. pair.wu@gmail.com.
Pewpan M IntapanResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. pewpan@kku.ac.th.
Hiroshi YamasakiDepartment of Parasitology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan. hyamasak@niid.go.jp.
Rutchanee RodpaiResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. rutchanee5020@gmail.com.
Porntip LaummaunwaiResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. porlau@kku.ac.th.
Tongjit ThanchomnangResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. thanchomnang@yahoo.com.
Oranuch SanpoolResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. sanpoolor@yahoo.com.
Kaoru KobayashiDivision of Research and Development, Adtec Inc., Oita, 879-0471, Japan. k-kobayashi@adtec-inc.co.jp.
Katsuyoshi TakayamaDivision of Research and Development, Adtec Inc., Oita, 879-0471, Japan. k-takayama@adtec-inc.co.jp.
Yukuharu KobayashiDivision of Research and Development, Adtec Inc., Oita, 879-0471, Japan. y-kobayashi@adtec-inc.co.jp.
Wanchai MaleewongResearch and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. wanch_ma@kku.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman gnathostomiasis is a serious tropical disease, which is often overlooked. There is an urgent need to improve tools to aid the potential diagnosis of the disease in endemic regions. To overcome this, we produced the immunochromatographic test (ICT) kit for a rapid and simple diagnosis of human gnathostomiasis.

findingsThe recombinant protein (named rGslic18) was applied to ICT kit as the antigen. The diagnostic value of ICT kit was evaluated using serum samples from parasitologically proven and clinically suspected gnathostomiasis patients, healthy volunteers and patients with other parasitic diseases. The ICT kit exhibited quite high sensitivity (93.75%) and specificity (97.01%).

conclusionsThe ICT kit is simple, convenient and easy to implement and expected to provide reliable diagnostic results for human gnathostomiasis. It also will be a promising diagnostic tool not only for large-scale epidemiological surveys in endemic or remote areas where diagnostic facilities are poor but also for a rapid clinical diagnosis in the bedside laboratory.

Indexed as

AnimalsAntibodiesChromatography, AffinityGnathostomiasisHumansReagent Kits, DiagnosticRecombinant ProteinsSensitivity and SpecificitySerologic TestsTime FactorsAntibodiesReagent Kits, DiagnosticRecombinant Proteins

Identifiers

PMID26754616
PMCPMC4710017

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.