Evidence map›Paper›PMID 26754479›Full record

ArticleJournal of autism and developmental disorders2016

Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome.

Emeline Crutcher, May Ali, John Harrison, Judit Sovago, Baltazar Gomez-Mancilla, Christian P Schaaf

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Emeline CrutcherTranslational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA.
May AliDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
John HarrisonAlzheimer Center, VU Medical Center, Amsterdam, The Netherlands.
Judit SovagoNovartis Pharmaceutical Corporation, Basel, Switzerland.
Baltazar Gomez-MancillaNovartis Pharmaceutical Corporation, Basel, Switzerland.
Christian P SchaafTranslational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA. schaaf@bcm.edu.ORCID http://orcid.org/0000-0002-2148-7490
Baylor College of Medicine · USNovartis (Switzerland) · CHAmsterdam UMC Location Vrije Universiteit Amsterdam · NL

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, SAMACO, RODNEY C · 2014 to 2019
$7.8M
NICHD NIH HHS 1U54 HD083092NICHD NIH HHS U54 HD083092
6 · The paper itself

Abstract

15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford-Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14-18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford-Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.

Indexed as

AdolescentAutistic DisorderChromosome DeletionChromosome DisordersChromosomes, Human, Pair 15CognitionFemaleHumansIntellectual DisabilityMaleNeuropsychological TestsSeizuresAutismCognitive functionCognitive testsIntellectual disabilityNeuropsychiatric disease

Identifiers

PMID26754479
PMCPMC5362964
OpenAlexW2233838673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.