ReviewDeutsches Arzteblatt international2015
Mechanical Thrombectomy in Stroke.
Review in Deutsches Arzteblatt international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Acute Ischemic Stroke Treatment in Germany (2015-2023): Nationwide Trends in Thrombolysis and Thrombectomy by Age and Sex.Brain sciences · 2025Article
- MicroCT and Histological Analysis of Clot Composition in Acute Ischemic Stroke : A Comparative Study of MT-Retrieved Clots and Clot Analogs.Clinical neuroradiology · 2024Article
- Mechanical thrombectomy for AIS from large vessel occlusion - current trends and future perspectives.Annals of medicine and surgery (2012) · 2023Review
- Tectonic infarct analysis: A computational tool for automated whole-brain infarct analysis from TTC-stained tissue.Heliyon · 2023Article
- Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia.BMC neuroscience · 2023Article
- Ceruletide and Alpha-1 Antitrypsin as a Novel Combination Therapy for Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.The Journal of experimental medicine · 2021Article
- A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke.Molecular & cellular proteomics : MCP · 2020Article
- Storage of blood clots for histological analysis: How long is too long in saline and paraformaldehyde?Histology and histopathology · 2020Article
- [Mothership or drip and ship?]Der Radiologe · 2019Review
- Endovascular Stroke Treatment on Single-Plane vs. Bi-Plane Angiography Suites : Technical Considerations and Evaluation of Treatment Success.Clinical neuroradiology · 2019Article
- Juvenile Stroke.Deutsches Arzteblatt international · 2017Review
- Cerebral Amyloid Angiopathy in Stroke Medicine.Deutsches Arzteblatt international · 2017Review
- In Reply.Deutsches Arzteblatt international · 2016Article
- Hemodilution.Deutsches Arzteblatt international · 2016Article
- Intra-arterial Treatment.Deutsches Arzteblatt international · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe introduction of neurological stroke units and of thrombolysis with the intravenous (IV) administration of recombinant tissue-type plasminogen activator (tPA) have markedly improved the treatment of stroke. Five randomized trials of catheter-based interventional treatment of stroke with special stents were published in 2015.
methodsRecently published randomized trials of mechanical thrombectomy are selectively reviewed.
resultsThese trials documented the clinical efficacy of mechanical thrombectomy (MT) in the treatment of occlusion of a major cerebral artery in the distribution of the internal carotid artery (evidence level 1a, recommendation grade A). Roughly 4-10% of all stroke patients could benefit from such an intervention. In the trials, 85% of the patients were first treated with IV-tPA. A recanalization of the occluded vessel was achieved by MT in 59-88% of patients. The percentage of patients with no deficit or only a mild deficit was 33-71% among those who received the intervention, compared to 19-40% in the control groups. The trial data indicate that MT is effective for elderly patients as well (age over 80). Thrombectomy did not increase the rate of secondary, symptomatic intracranial hemorrhage.
conclusionMT can only be used to treat the occlusion of major cerebral arteries. In appropriate patients, it expands the spectrum of treatment options for stroke. Long-term data are not yet available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.