Evidence map›Paper›PMID 26754070›Full record

ArticleInternational journal of colorectal disease2016

Complication and local recurrence rate after endoscopic resection of large high-risk colorectal adenomas of ≥3 cm in size.

J Seidel, E Färber, R Baumbach, W Cordruwisch, U Böhmler, B Feyerabend, S Faiss

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Management of complex polyps of the colon and rectum.International journal of colorectal disease · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

J SeidelDepartment of Gastroenterology & Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Medical Faculty, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany.
E FärberDepartment of Gastroenterology & Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Medical Faculty, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany.
R BaumbachDepartment of Gastroenterology & Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Medical Faculty, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany.
W CordruwischDepartment of Gastroenterology & Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Medical Faculty, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany.
U BöhmlerDepartment of Gastroenterology & Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Medical Faculty, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany.
B FeyerabendMVZ Hanse Histologikum GmbH, Fangdieckstr. 75, 22547, Hamburg, Germany.
S FaissDepartment of Gastroenterology & Interventional Endoscopy, Asklepios Hospital Barmbek, Semmelweis University, Medical Faculty, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany. s.faiss@asklepios.com.
Asklepios Klinik Barmbek · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEndoscopic resection is a widely used technique for treatment of large colorectal adenomas, but few data are available including only lesions larger than ≥2 cm. The aim of this study is to evaluate the complication and recurrence rate after endoscopic resection of high-risk colorectal adenomas ≥3 cm in size.

methodsRetrospective analysis of a prospectively maintained database of patients undergoing polypectomy of large colorectal polyps of ≥3 cm.

resultsIn 341 patients, 360 colorectal adenomas with a mean size of 3.9 cm were resected endoscopically. In 25 patients, a complication including 22 delayed bleedings (6.5%) and three perforations (0.9%) occurred. Single-variate analysis showed an increasing risk of complications for larger adenomas (3.9 vs. 4.6 cm; p ≤ 0.05). Two hundred twelve patients with 224 adenomas had undergone at least one documented follow-up endoscopy with a medium follow-up period of 16 months. In 95 resected lesions (42.4%), a residual adenoma occurred in the first follow-up colonoscopy (n = 88, 92.6%) or a recurrent adenoma occurred after at least one negative follow-up colonoscopy (n = 7, 7.4%). In multivariate analysis, risk factors were lesion size, sessile growth pattern, and the performing endoscopist. The complication and recurrence rate correlated inversely between endoscopists.

conclusionsThe present study is the largest study showing complication and recurrence rates after colorectal polypectomy of advanced colorectal adenomas of ≥3 cm in size. Polyp size was identified as the most important risk factor for complications. For the first time, this study shows that the complication rate after colorectal polypectomy of large adenomas is correlated inversely with the residual and/or recurrence rate.

Indexed as

AdenomaAdultAgedAged, 80 and overColorectal NeoplasmsEndoscopy, GastrointestinalFemaleFollow-Up StudiesHumansIntestinal MucosaMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm, ResidualNeoplasm StagingPostoperative ComplicationsColorectal adenomaColorectal polypComplicationEndoscopic mucosal resectionPolypectomyRecurrence

Identifiers

PMID26754070
OpenAlexW2290945133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.