ArticleThe American journal of gastroenterology2016
Worldwide Inverse Association between Gastric Cancer and Esophageal Adenocarcinoma Suggesting a Common Environmental Factor Exerting Opposing Effects.
Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Multicentric randomised study ofBMJ open · 2017Trial
- Trends and Disparities in Mortality Due to Gastric Malignancies the United States: A Nationwide Analysis from 1999 to 2020.Journal of gastrointestinal cancer · 2025Article
- Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma.Cell reports. Medicine · 2025Article
- Adherence to guideline recommendations for Barrett's esophagus (BE) surveillance endoscopies: Effects of dedicated BE endoscopy lists.Endoscopy international open · 2023Article
- The Protease Inhibitor Amprenavir Protects against Pepsin-Induced Esophageal Epithelial Barrier Disruption and Cancer-Associated Changes.International journal of molecular sciences · 2023Article
- Symptoms of total pain experienced by older people with advanced gastrointestinal cancer receiving palliative chemotherapy.European journal of cancer care · 2022Article
- Cytosponge-TFF3 Testing can Detect Precancerous Mucosal Changes of the Stomach.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- The Influence of Heavy Metals on Gastric Tumorigenesis.Journal of oncology · 2022Article
- Molecular characterization of Barrett's esophagus at single-cell resolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Oligometastatic Adenocarcinoma of the Esophagus: Current Understanding, Diagnosis, and Therapeutic Strategies.Cancers · 2021Review
- Prognostic factors affecting long-term outcomes in patients with brain metastasis from esophageal carcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Surveillance strategy of Barrett's esophagus in the Asian region with particular reference to its locoregional epidemiology.JGH open : an open access journal of gastroenterology and hepatology · 2020Review
- Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas.Journal of gastric cancer · 2020Article
- Expressions of CD23, IL-17 and MMP-9 in Patients with Colorectal Cancer.Iranian journal of public health · 2020Article
- What is causing the rising incidence of esophageal adenocarcinoma in the West and will it also happen in the East?Journal of gastroenterology · 2019Review
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- Predicting the Future Burden of Esophageal Cancer by Histological Subtype: International Trends in Incidence up to 2030.The American journal of gastroenterology · 2017Article
- Past, present and future of Barrett's oesophagus.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2017Review
- The Relationship Between Gastric and Esophageal Cancers in Italy.The American journal of gastroenterology · 2016Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesThe incidence of esophageal adenocarcinoma (EAC) is increasing while adenocarcinoma of the stomach is decreasing. We have investigated whether the incidences of these two cancers and their time trends might be inversely related pointing to a common environmental factor exerting opposite effects on these cancers.
methodsFor cross-sectional analyses data were abstracted from "Cancer Incidence in Five Continents" (CI5) Volume X and GLOBOCAN 2012. Relevant ICD-10 codes were used to locate esophageal and gastric cancers anatomically, and ICD-O codes for the histological diagnosis of EAC. For longitudinal analyses, age standardized rates (ASRs) of EAC and total gastric cancer (TGC) were extracted from CI5C-Plus.
resultsEstimated (2012) ASRs were available for 51 countries and these showed significant negative correlations between EAC and both TGC (males: correlation coefficient (CC)=-0.38, P=0.006, females: CC=-0.41, P=0.003) and non-cardia gastric cancer rates (males: CC=-0.41, P=0.003 and females: CC=-0.43, P=0.005). Annual incidence trends were analyzed for 38 populations through 1989-2007 and showed significant decreases for TGC in 89% and increases for EAC in 66% of these, with no population showing a fall in the latter. Significant negative correlation between the incidence trends of the two cancers was observed in 27 of the 38 populations over the 19-50 years of available paired data. Super-imposition of the longitudinal and cross-sectional data indicated that populations with a current high incidence of EAC and low incidence of gastric cancer had previously resembled countries with a high incidence of gastric cancer and low incidence of EAC.
conclusionsThe negative association between gastric cancer and EAC in both current incidences and time trends is consistent with a common environmental factor predisposing to one and protecting from the other.
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