SynthesisThe American journal of gastroenterology2016
Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis.
Synthesis in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Artificial Intelligence in the Characterization of Small and Diminutive Colorectal Polyps: A Prospective Study in a Clinical Setting Using CAD EYE®
Assessing the Agreement Between Endoscopic and Histopathological Diagnosis of Colorectal Sessile Serrated Lesions.
Who cites it
81 citing papers in PubMed, 5 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Thermal ablation of margins for recurrence prevention after endoscopic mucosal resection: a systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- Diagnosis and management of small bowel obstruction in virgin abdomen: a WSES position paper.World journal of emergency surgery : WJES · 2021Guideline
- Impact of SARS-CoV-2 Pandemic on Colorectal Cancer Screening Delay: Effect on Stage Shift and Increased Mortality.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Pooled it
- Risk factors associated with longer cecal intubation time: a systematic review and meta-analysis.International journal of colorectal disease · 2018Pooled it
- Efficacy and Safety of Linaclotide as an Adjunct to Polyethylene Glycol in Bowel Preparation: A Meta-Analysis.Journal of digestive diseasesPooled it
- The effectiveness of walking exercise on the bowel preparation before colonoscopy: a single blind randomized clinical trial study.BMC gastroenterology · 2023Trial
- Precision Patient Navigation to Improve Rates of Follow-up Colonoscopy, An Individual Randomized Effectiveness Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Trial
- Comparison of adenoma detection by colonoscopy between polypectomy performed during both insertion and withdrawal versus during withdrawal only: a multicenter, randomized, controlled trial.Surgical endoscopy · 2020Trial
- A Randomized Trial Comparing the Bowel Cleansing Efficacy of Sodium Picosulfate/Magnesium Citrate and Polyethylene Glycol/Bisacodyl (The Bowklean Study).Scientific reports · 2020Trial
- Knowledge, Attitudes, and Practices Regarding Colorectal Cancer Screening Among Medical Residents: An Exploratory, Single-Center, Cross-Sectional Study from Egypt.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Abdominal binders improve colonoscopy outcomes: a systematic review and meta-analysis of randomized controlled trials with BMI-stratified subgroup analysis.Therapeutic advances in gastroenterology · 2026Article
- Structured light radial-view endoscope PROBE for IMAGING of colorectal tissue.Optics letters · 2025Article
- Socioeconomic disparities: a more important risk factor for advanced-stage oral cancer in Florida than smoking?Cancer causes & control : CCC · 2025Article
- The Molecular Landscape of Colorectal Laterally Spreading Tumors: From Endoscopic Subtypes to Molecular Targets.International journal of molecular sciences · 2025Review
- A Comparison of the Australian Colonoscopy Care Standards to Current Clinical Practice.Health science reports · 2025Article
- Current Perspectives on Colorectal Cancer Screening and Surveillance in the Geriatric Population.Current gastroenterology reports · 2025Review
- Polyp-Size: A Precise Endoscopic Dataset for AI-Driven Polyp Sizing.Scientific data · 2025Article
- Does Colonoscopy as a First Screening Test Still Make Sense?-Counterpoint.Digestive diseases and sciences · 2025Review
- The Reliability and Quality of Videos as Guidance for Gastrointestinal Endoscopy: Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Mapping the colorectal cancer patient journey in Egypt: A qualitative study of diagnosis, treatment, and lifestyle perspectives.PloS one · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesObservational studies have shown that colonoscopy reduces colorectal cancer (CRC) incidence and mortality in the general population. We aimed to conduct a meta-analysis quantifying the magnitude of protection by colonoscopy, with screening and diagnostic indications, against CRC in patients with non-malignant findings and demonstrating the potentially more marked effect of screening over diagnostic colonoscopy.
methodsPubMed, EMBASE, and conference abstracts were searched through 30 April 2015. The primary outcomes were overall CRC incidence and mortality. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random-effect models.
resultsEleven observational studies with a total of 1,499,521 individuals were included. Pooled analysis showed that colonoscopy was associated with a 61% RR reduction in CRC incidence (RR: 0.39; 95% CI: 0.26-0.60; I(2)=93.6%) and a 61% reduction in CRC mortality (RR: 0.39; 95% CI: 0.35-0.43; I(2)=12.0%) in patients with non-malignant findings, although there was high heterogeneity for the outcome of CRC incidence. After excluding one outlier study, there was low heterogeneity for the outcome of incidence (I(2)=44.7%). Subgroup analysis showed that the effect of screening colonoscopy was more prominent, corresponding to an 89% reduction in CRC incidence (RR: 0.11; 95% CI: 0.08-0.15), in comparison with settings involving diagnostic colonoscopy (RR: 0.51; 95% CI: 0.43-0.59; P<0.001).
conclusionsOn the basis of this meta-analysis of observational studies, CRC incidence and mortality in patients with non-malignant findings are significantly reduced after colonoscopy. The effect of screening colonoscopy on CRC incidence is more marked than diagnostic colonoscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.