ArticleDevelopment and psychopathology2017
Parent and peer influences on emerging adult substance use disorder: A genetically informed study.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.Behavior genetics · 2019Pooled it
- Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression.Translational psychiatry · 2019Trial
- Service user and healthcare-worker perspectives on Substance Use Disorder treatment journeys, relapse, and recovery in Sub-Saharan Africa: Evidence from Uganda.PLOS global public health · 2026Article
- Patterns of childhood maltreatment and maternal substance use disorder on the development of emerging adult offspring substance use.Developmental psychology · 2025Article
- The relative effects of parental alcohol use disorder and maltreatment on offspring alcohol use: Unique pathways of risk.Development and psychopathology · 2024Article
- Military service and risk of subsequent drug use disorders among Swedish men.Social psychiatry and psychiatric epidemiology · 2023Article
- Contextual, structural, and mental health experiences of children of women engaged in high-risk sexual behaviour in Kampala: a mixed method study.Frontiers in public health · 2023Article
- The role of adolescent social relationships in promoting alcohol resistance: Interrupting the intergenerational transmission of alcohol misuse.Development and psychopathology · 2022Article
- Gene-by-peer-environment interaction effects on cigarette, alcohol, and marijuana use among US high school students of European Ancestry.Social science & medicine (1982) · 2022Article
- Substance Use among Youth in Community and Residential Mental Health Care Facilities in Ontario, Canada.International journal of environmental research and public health · 2022Article
- "I Grew Up Amidst Alcohol and Drugs:" a Qualitative Study on the Lived Experiences of Parental Substance Use Among Adults Who Developed Substance Use Disorders Themselves.Frontiers in psychiatry · 2022Article
- Mother and Father Prescription Opioid Misuse, Alcohol Use Disorder, and Parent Knowledge in Pathways to Adolescent Alcohol Use.Journal of youth and adolescence · 2020Article
- Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.Journal of youth and adolescence · 2020Article
- Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents.International journal of environmental research and public health · 2019Article
- Predicting Substance Use Patterns Among Rural Adults: The Roles of Mothers, Fathers, and Parenthood.Family process · 2019Article
- Adolescent Depression and Substance Use: the Protective Role of Prosocial Peer Behavior.Journal of abnormal child psychology · 2019Article
- Intergenerational Continuity in Substance Abuse: Does Offspring's Friendship Network Make a Difference?The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018Article
- Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students.Journal of studies on alcohol and drugs · 2018Article
- Mental Health Symptoms and Parenting Among Father-Only and Dual Substance Use Disorder Couples.Journal of family issues · 2018Article
- Developmental Etiologies of Alcohol Use and Their Relations to Parent and Peer Influences Over Adolescence and Young Adulthood: A Genetically Informed Approach.Alcoholism, clinical and experimental research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The present study utilizes longitudinal data from a high-risk community sample to examine the unique effects of genetic risk, parental knowledge about the daily activities of adolescents, and peer substance use on emerging adult substance use disorders (SUDs). These effects are examined over and above a polygenic risk score. In addition, this polygenic risk score is used to examine gene-environment correlation and interaction. The results show that during older adolescence, higher adolescent genetic risk for SUDs predicts less parental knowledge, but this relation is nonsignificant in younger adolescence. Parental knowledge (using mother report) mediates the effects of parental alcohol use disorder (AUD) and adolescent genetic risk on risk for SUD, and peer substance use mediates the effect of parent AUD on offspring SUD. Finally, there are significant gene-environment interactions such that, for those at the highest levels of genetic risk, less parental knowledge and more peer substance use confers greater risk for SUDs. However, for those at medium and low genetic risk, these effects are attenuated. These findings suggest that the evocative effects of adolescent genetic risk on parenting increase with age across adolescence. They also suggest that some of the most important environmental risk factors for SUDs exert effects that vary across level of genetic propensity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.