ArticleInternational orthopaedics2016
Risk factors for bone cement leakage in percutaneous vertebroplasty: a retrospective study of four hundred and eighty five patients.
Article in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Risk factors for new vertebral compression fracture following percutaneous vertebral augmentation: a systematic review and meta-analysis based on multivariate logistic regression analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Whether the Unilateral Transverse Process-pedicle Approach has Advantages over the Traditional Transpedicle Approach: A Systematic review and Meta-analysis.Zeitschrift fur Orthopadie und Unfallchirurgie · 2023Pooled it
- Effectiveness and safety of percutaneous kyphoplasty combined with zoledronic acid in treatment of osteoporotic vertebral compression fractures: a meta-analysis.Archives of orthopaedic and trauma surgery · 2022Pooled it
- A Nomogram to Predict Intra-Spinal Canal Cement Leakage Among Elderly Patients with Spine Metastases: An Internal-Validated Model.Clinical interventions in aging · 2021Trial
- Stentoplasty with Resorbable Calcium Salt Bone Void Fillers for the Treatment of Vertebral Compression Fracture: Evaluation After 3 Years.Clinical interventions in aging · 2021Trial
- Percutaneous curved vertebroplasty in the treatment of thoracolumbar osteoporotic vertebral compression fractures.The Journal of international medical research · 2019Trial
- A Deep Learning-Based Multimodal Fusion Model for Predicting Bone Cement Leakage in Percutaneous Kyphoplasty: Development and Validation.JOR spine · 2026Article
- Cement leakage and post-operative outcomes after lower-versus higher-volume bone cement injection in percutaneous vertebroplasty: a systematic review and meta-analysis of randomized controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Vertebral infection after kyphoplasty: distinguishing misdiagnosis from true postoperative infection and implications for management.Journal of orthopaedic surgery and research · 2026Article
- Percutaneous vertebroplasty and percutaneous kyphoplasty for osteoporotic vertebral compression fractures: medium- and long-term evaluation of clinical outcomes and affecting factors.BMC musculoskeletal disorders · 2026Article
- Association of preoperative vertebral kyphosis and other factors with cement leakage after percutaneous kyphoplasty: a retrospective cohort study.BMC surgery · 2026Article
- Delayed intradural hourglass-shaped bone cement leakage after percutaneous vertebroplasty: a case report.Journal of medical case reports · 2026Article
- The impact of different bone cement distribution patterns on cement leakage in percutaneous curved vertebroplasty versus bilateral percutaneous vertebroplasty.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Current Evidence and Clinical Implications of Full-Endoscopic Spine Surgery for Post-Vertebroplasty Lumbar Radiculopathy: A Comprehensive Review.Journal of pain research · 2026Review
- Impact of bone cement leakage on early postoperative pain in percutaneous vertebroplasty for osteoporotic vertebral compression fractures.Frontiers in surgery · 2026Article
- Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis.European journal of medical research · 2025Article
- Percutaneous vertebral augmentation for osteoporotic vertebral compression fractures: minimally invasive techniques and clinical outcomes.European journal of medical research · 2025Review
- The effectiveness of Valsalva Maneuver-Assisted percutaneous vertebroplasty in reducing cement leakage in osteoporotic vertebral compression fractures.BMC musculoskeletal disorders · 2025Article
- Interpretable Machine Learning Model to Predict Bone Cement Leakage in Percutaneous Vertebral Augmentation for Osteoporotic Vertebral Compression Fracture Based on SHapley Additive exPlanations.Global spine journal · 2025Article
- Timing of percutaneous vertebroplasty in the management of osteoporotic vertebral compression fractures: a retrospective cohort study.Frontiers in surgery · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePercutaneous vertebroplasty (PVP) is a common procedure in spine surgery. Bone cement leakage is the most common complication related to this procedure. The purpose of this study was to assess the incidence and risk factors for cement leakage after PVP.
methodsA total of 485 patients who underwent PVP between August 2003 and August 2013 were enrolled in the study. Clinical and radiological characteristics, including age, gender, diagnosis, operated level, surgical approach, type of anesthesia, volume of bone cement, fracture type, and fracture severity, were considered as potential risk factors. Cement leakage was assessed based on post-operative imaging examination. Six types of leakage were defined and risk factors for each type were analyzed.
resultsThe incidence of leakage was 58.2 %. Binary logistic analysis revealed that larger volume of bone cement (P < 0.001) and higher fracture severity grade (P < 0.001) were the strongest independent risk factors. Univariate analysis and multinomial logistic analysis showed that surgical approach (P < 0.001), gender (P = 0.016), and operated level (P = 0.032) were additional risk factors for leakage. Further analysis showed that more bone cement was used in bilateral than unilateral approaches, that men had larger volumes of bone cement injected than women, and that more bone cement was injected into lumbar vertebrae than thoracic vertebrae. Therefore, these risk factors (surgical approach, gender, and operated level) could be attributed to excess bone cement usage.
conclusionsCement leakage is very common with PVP. Higher fracture severity grade and larger volume of bone cement were the two strongest independent risk factors for leakage.
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