ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2016
The relation of serum uric acid levels with L-Dopa treatment and progression in patients with Parkinson's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- Association between wide-ranging food intake and Parkinson's disease: a comprehensive mendelian randomization study.Scientific reports · 2025Article
- The impact of uric acid levels in the pathophysiology and its contribution to the prediction of diagnosis in restless legs syndrome.Sleep and biological rhythms · 2025Article
- Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease.Biology of sex differences · 2023Article
- Decreased Serum Uric Acid Level as an Indicator of Altered Oxidative Balance in Patients With Migraine.Cureus · 2022Article
- Life style and Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Evaluation of serum uric levels in migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Metabolomic Profiling of Aqueous Humor and Plasma in Primary Open Angle Glaucoma Patients Points Towards Novel Diagnostic and Therapeutic Strategy.Frontiers in pharmacology · 2021Article
- Agricultural work and reduced circulating uric acid are both associated with initial hospital admission for Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- The Relationship Between Serum Uric Acid Levels and Clinical Features in Essential Tremor.Noro psikiyatri arsivi · 2020Article
- Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease.Molecular neurodegeneration · 2019Review
- Effect of serum uric acid on cognition in patients with idiopathic REM sleep behavior disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease.Medicine · 2018Observational
- Changes in the Serum Urate Level Can Predict the Development of Parkinsonism in the 6-Hydroxydopamine Animal Model.Neurochemical research · 2018Article
- Association of variants in microRNA with Parkinson's disease in Chinese Han population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study.Oncotarget · 2017Article
- Role of Diet and Nutritional Supplements in Parkinson's Disease Progression.Oxidative medicine and cellular longevity · 2017Article
- Advances in clinical neurology through the journal "Neurological Sciences" (2015-2016).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we aimed to investigate the association of the serum uric acid (UA) level with disease progression and L-Dopa treatment in PD (Parkinson's disease) patients. Serum UA levels of 80 consecutive PD patients were measured and were matched according to age and sex with 80 healthy controls. The patients were divided into two subgroups according to the pharmaceutical treatment received. First group consisted of patients treated with L-Dopa and a dopamine agonist and the second group consisted of patients treated only with a dopamine agonist. The patients were divided into two other subgroups according to Hoehn and Yahr scale. First group consisted of patients at the first two stages and the second group included patients at the third and upper stages. PD patients were found to have significantly lower levels of serum UA than controls (p = 0.000). Serum UA levels were lower in the group under L-Dopa + dopamine agonist treatment and in patients at third and upper Hoehn and Yahr stages than the patients under only dopamine agonist treatment and in the patients at the first two stages (p = 0.000 and p = 0.000). Multivariate logistic regression showed that advanced stages (OR 0.65, CI 0.50-0.79, p = 0.000) and L-Dopa treatment (OR 1.08, CI 1.03-1.16, p = 0.001) were independently associated with low UA levels. Our study supports that there is an inverse relation between UA levels and L-Dopa treatment and PD stages, and high serum UA levels may decrease the oxidative stress taking part in the pathogenesis of PD.
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