ArticlePsychopharmacology2016
A prospective, longitudinal study of sleep disturbance and comorbidity in opiate dependence (the ANRS Methaville study).
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Prevalence of sleep-related symptoms in patients receiving methadone maintenance treatment: a systematic review and meta-analysis.Addiction science & clinical practice · 2026Pooled it
- Smoking and risk of sleep-related issues: a systematic review and meta-analysis of prospective studies.Canadian journal of public health = Revue canadienne de sante publique · 2020Pooled it
- Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).PloS one · 2017Trial
- Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study.Addiction (Abingdon, England) · 2026Article
- Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats.PloS one · 2025Article
- Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review.Current addiction reports · 2024Article
- Feasibility and acceptability of wearing a neuromodulation device at night in individuals in recovery from opioid use disorder.Frontiers in psychiatry · 2024Article
- Wireless electroencephalography (EEG) to monitor sleep among patients being withdrawn from opioids: Evidence of feasibility and utility.Experimental and clinical psychopharmacology · 2022Article
- Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.Clinics in chest medicine · 2022Review
- At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Crosstalk between Sleep Disturbance and Opioid Use Disorder: A Narrative Review.Addiction & health · 2020Review
- Multimodal assessment of sleep in men and women during treatment for opioid use disorder.Drug and alcohol dependence · 2020Article
- Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan.Neuropsychiatric disease and treatment · 2018Article
- Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.Addictive behaviors · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE/
objectivesSleep disturbance is frequent in opioid-dependent patients. To date, no data are available about the impact of methadone maintenance treatment on sleep disturbance. Using 1-year follow-up data from the Methaville trial, we investigated the impact of methadone initiation and other correlates on sleep disturbance in opioid-dependent patients.
methodsSleep disturbance severity was evaluated using two items from different scales (Center for Epidemiological Studies Depression Scale for depression and Opiate Treatment Index). We assessed the effect of methadone and other correlates on sleep disturbance severity during follow-up (months 0, 6, and 12) using a mixed multinomial logistic regression model.
resultsWe included 173 patients who had 1-year follow-up data on sleep disturbance, corresponding to 445 visits. At enrolment, 60.5 % reported medium to severe sleep disturbance. This proportion remained stable during methadone treatment: 54.0 % at month 6 and 55.4 % at month 12. The final multivariate model indicated that younger patients (odds ratio (OR) [95 % CI] 0.95 [0.90-1.00]), patients with pain (OR [95 % CI] 2.45 [1.13-5.32]), patients with high or very high nicotine dependence (OR [95 % CI] 5.89 [2.41-14.39]), and patients at suicidal risk (2.50 [1.13-5.52]) had a higher risk of severe sleep disturbance. Because of collinearity between suicidal risk and attention deficit hyperactivity disorder (ADHD) symptoms, ADHD was not associated with sleep disturbance in the final model. Receiving methadone treatment had no significant effect on sleep disturbance.
conclusionsSleep disturbance is frequent among opioid-dependent patients. It can be regarded as an important signal of more complex psychiatric comorbidities such as suicidal risk and ADHD. However, sleep disturbance should not be considered an obstacle to methadone maintenance treatment (MMT) initiation or continuation.
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