ArticleItalian journal of pediatrics2016
Diagnostic role of inflammatory markers in pediatric Brucella arthritis.
Article in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Quantifying research hotspots and trends in brucella spondylitis: a bibliometric analysis.Frontiers in surgery · 2024Pooled it
- Retrospective case-control study of haematological indices and inflammatory ratios in the diagnosis of paediatric brucellosis.BMC infectious diseases · 2026Article
- Inflammation-driven pathogenesis of hyperemesis gravidarum: assessing the role of pan-immune-inflammation value and hematologic parameters.Archives of gynecology and obstetrics · 2025Article
- Platelet mass index, systemic immune-inflammation index, and neutrophil-lymphocyte ratio as practical markers in childhood brucellosis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Observational
- Can Hematological Inflammatory Indices Be Used to Differentiate Modic Type 1 Changes from Brucella Spondylodiscitis?Medicina (Kaunas, Lithuania) · 2024Article
- Article
- An Elevated Neutrophil-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Liver Cancer after Interventional Treatments.BioMed research international · 2022Article
- Article
- Comparison of Inflammatory Markers between Adult and Pediatric Brucellosis Patients.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis.Journal of blood medicine · 2020Article
- Significance of Pretreatment Neutrophil-to-Lymphocyte Ratio in Mucoepidermoid Carcinoma of Pediatrics: A Multicenter Study.Frontiers in pediatrics · 2020Article
- Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Pediatric Parotid Cancer.Frontiers in pediatrics · 2019Article
- Sixteen Chinese pediatric brucellosis patients onset of fever in non-epidemic areas and 8 developed with osteoarticular involvement.Clinical rheumatology · 2018Article
- Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis.The Korean journal of internal medicine · 2017Article
- Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.Italian journal of pediatrics · 2017Review
- Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case-control study.Journal of laboratory physiciansArticle
- Brucellar arthritis and sacroiliitis: an 8-year retrospective comparative analysis of demographic, clinical, and paraclinical features.Therapeutic advances in infectious diseaseArticle
- Comparison of inflammatory markers between brucella and non-brucella epididymo-orchitis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a multisystem infectious disease, there is an inflammation, which causes increase in acute phase reactants in brucellosis. The mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate diagnostic values of these biomarkers in brucella arthritis (BA).
methodsThe study included 64 children with BA and 66 healthy control subjects. Demographic features, joint involvement, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and hematological variables were retrospectively recorded. In addition, results of synovial fluid and serum tube agglutination test for brucella together with treatment regimens were recorded.
resultsThe mean age of the patients (53.1 % male) was 92.3 ± 41.2 months. The most commonly affected joint was ankle (53.1 %). Synovial fluid puncture-brucella agglutination test was positive in 22 (34.3 %) patients. Puncture culture was positive in 9 patients. Most of the patients (57.8 %) were treated with a combination of rifampicin plus sulfamethoxazole/trimethoprim and gentamicin. Significantly higher mean PDW, RDW, MPV, NLR and PLR values were found in children with BA compared to control subjects (p < 0.05). A positive correlation was found between MPV and NLR values (R (2) = 0.192, p < 0.001).
conclusionOur findings indicated that NLR and PLR are indirect markers of inflammation that may be observed abnormally increased in children with brucella arthritis. Further longitudinal studies are needed to investigate this topic to establish the more clear associations.
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