ArticleJournal of nanobiotechnology2016
Electrophoretic deposition of ligand-free platinum nanoparticles on neural electrodes affects their impedance in vitro and in vivo with no negative effect on reactive gliosis.
Article in Journal of nanobiotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Nanoporous platinum microelectrode arrays for neuroscience applications.RSC advances · 2025Article
- Anti-biofilm properties of laser-synthesized, ultrapure silver-gold-alloy nanoparticles against Staphylococcus aureus.Scientific reports · 2024Article
- Advances in electrode interface materials and modification technologies for brain-computer interfaces.Biomaterials translational · 2023Review
- Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition.Advanced healthcare materials · 2022Article
- Development and Characterization of Novel Conductive Sensing Fibers for In Vivo Nerve Stimulation.Sensors (Basel, Switzerland) · 2021Article
- Carbon-Nanotube-Coated Surface Electrodes for Cortical Recordings In Vivo.Nanomaterials (Basel, Switzerland) · 2021Article
- Technology of deep brain stimulation: current status and future directions.Nature reviews. Neurology · 2021Review
- Biocompatibility of Platinum Nanoparticles in BrainFrontiers in neuroscience · 2021Article
- Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation.Advanced functional materials · 2018Article
- In Vivo Neural Recording and Electrochemical Performance of Microelectrode Arrays Modified by Rough-Surfaced AuPt Alloy Nanoparticles with Nanoporosity.Sensors (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrodes for neural stimulation and recording are used for the treatment of neurological disorders. Their features critically depend on impedance and interaction with brain tissue. The effect of surface modification on electrode impedance was examined in vitro and in vivo after intracranial implantation in rats. Electrodes coated by electrophoretic deposition with platinum nanoparticles (NP; <10 and 50 nm) as well as uncoated references were implanted into the rat's subthalamic nucleus. After postoperative recovery, rats were electrostimulated for 3 weeks. Impedance was measured before implantation, after recovery and then weekly during stimulation. Finally, local field potential was recorded and tissue-to-implant reaction was immunohistochemically studied.
resultsCoating with NP significantly increased electrode's impedance in vitro. Postoperatively, the impedance of all electrodes was temporarily further increased. This effect was lowest for the electrodes coated with particles <10 nm, which also showed the most stable impedance dynamics during stimulation for 3 weeks and the lowest total power of local field potential during neuronal activity recording. Histological analysis revealed that NP-coating did not affect glial reactions or neural cell-count.
conclusionsCoating with NP <10 nm may improve electrode's impedance stability without affecting biocompatibility. Increased impedance after NP-coating may improve neural recording due to better signal-to-noise ratio.
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