ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Greater serum carotenoid concentration associated with higher bone mineral density in Chinese adults.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 36 citations in OpenAlex.
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- Evaluation of bone-protecting effects of palm carotene mixture in two- and three-dimensional osteoblast/osteoclast co-culture systems.International journal of medical sciences · 2025Article
- Lutein Maintains Bone Mass In Vitro and In Vivo Against Disuse-Induced Bone Loss in Hindlimb-Unloaded Mice.Nutrients · 2024Article
- Effects and Mechanisms of Lutein on Aging and Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024Review
- Associations between blood antioxidant levels and femoral neck strength.BMC musculoskeletal disorders · 2023Article
- Aging and antioxidants: the impact of dietary carotenoid intakes on soluble klotho levels in aged adults.Frontiers in endocrinology · 2023Article
- Dietary carotenoid intake and osteoporosis: the National Health and Nutrition Examination Survey, 2005-2018.Archives of osteoporosis · 2021Article
- Vitamin A and Bone Health: A Review on Current Evidence.Molecules (Basel, Switzerland) · 2021Review
- Effects ofFoods (Basel, Switzerland) · 2021Article
- In Vitro Biological Activities of Fruits and Leaves ofAntioxidants (Basel, Switzerland) · 2020Article
- Carotenoids: How Effective Are They to Prevent Age-Related Diseases?Molecules (Basel, Switzerland) · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThis cross-sectional study has been performed to investigate the relationship between serum carotenoids and bone mineral density (BMD) in Chinese population. We found that women with higher serum β-cryptoxanthin, lycopene, or α-carotene exhibited higher BMD at various bone sites. Similar association was observed between α-carotene and BMD in men.
introductionCarotenoids may positively regulate bone metabolism through their antioxidant properties; however, few studies have examined the relation between serum carotenoids and bone health. We aimed to determine the associations between the serum concentration of several carotenoid subclasses and BMD in a Chinese population.
methodsThis study was a community-based cross-sectional study. We measured 1898 women and 933 men aged 59.6 years who completed serum β-cryptoxanthin, zeaxanthin + lutein, lycopene, and α-carotene concentration analyses and BMD assessments. Serum individual carotenoids were assessed by the methods of reverse-phase high-performance liquid chromatography. Dual-energy X-ray absorptiometry was applied to determine BMD at whole body, lumbar spine, total hip, femur neck, and trochanter. ANCOVA was used to examine the correlations between categorized individual carotenoids and BMD at measured sites.
resultsAfter adjusting for potential covariates, a monotonic dose-response positive correlation between circulating levels of β-cryptoxanthin, lycopene, and α-carotene and BMD at various skeletal sites was observed in women. Women in the top (vs. bottom) quartiles of serum β-cryptoxanthin, lycopene, or α-carotene exhibited 1.8-2.3, 1.5-2.0, or 1.3-2.7 % higher BMD at the bone sites with significant results (P-trend <0.05), respectively. For men, the corresponding values were 2.6-4.0 % for α-carotene at the whole body and hip regions (P-trend <0.001-0.023).
conclusionThese results suggest that serum carotenoids have a favorable association with bone health in the study population, especially in women.
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