Evidence map›Paper›PMID 26753125›Full record

ArticleCurrent tissue engineering

Recent Scientific Advances Towards the Development of Tendon Healing Strategies.

Eli T Sayegh, John D Sandy, Mandeep S Virk, Anthony A Romeo, Robert W Wysocki, Jorge O Galante, Katie J Trella, Anna Plaas, Vincent M Wang

Abstract read
In one paragraph

Article in Current tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Recent advances in tendinopathy.Faculty reviews · 2020
    Review
  11. Immunology Guides Skeletal Muscle Regeneration.International journal of molecular sciences · 2018
    Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eli T SayeghDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
John D SandyDepartment of Biochemistry, Rush University Medical Center, Chicago, IL 60612.
Mandeep S VirkDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
Anthony A RomeoDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
Robert W WysockiDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
Jorge O GalanteDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
Katie J TrellaDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.
Anna PlaasDepartment of Rheumatology/Internal Medicine, Rush University Medical Center, Chicago, IL 60612.
Vincent M WangDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612.

Funding

Promoting Healing of Tendinopathies Using Therapeutic Mechanobiologic Stimulation for Targeted Removal of Aggrecan-Rich DepositsR01AR063144 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, VINCENT M · 2013 to 2018
$1.5M
NIAMS NIH HHS R01 AR063144
6 · The paper itself

Abstract

There exists a range of surgical and non-surgical approaches to the treatment of both acute and chronic tendon injuries. Despite surgical advances in the management of acute tears and increasing treatment options for tendinopathies, strategies frequently are unsuccessful, due to impaired mechanical properties of the treated tendon and/or a deficiency in progenitor cell activities. Hence, there is an urgent need for effective therapeutic strategies to augment intrinsic and/or surgical repair. Such approaches can benefit both tendinopathies and tendon tears which, due to their severity, appear to be irreversible or irreparable. Biologic therapies include the utilization of scaffolds as well as gene, growth factor, and cell delivery. These treatment modalities aim to provide mechanical durability or augment the biologic healing potential of the repaired tissue. Here, we review the emerging concepts and scientific evidence which provide a rationale for tissue engineering and regeneration strategies as well as discuss the clinical translation of recent innovations.

Indexed as

biomechanicsextracellular matrixhealingTendinopathytherapeutics

Identifiers

PMID26753125
PMCPMC4706369

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.