Evidence map›Paper›PMID 26753099›Full record

ArticleJournal of translational science2015

Molecular analysis of CD133-positive circulating tumor cells from patients with metastatic castration-resistant prostate cancer.

Edwin E Reyes, Marc Gillard, Ryan Duggan, Kristen Wroblewski, Steven Kregel, Masis Isikbay, Jacob Kach, Hannah Brechka, David J Vander Weele, Russell Z Szmulewitz and 1 more

Abstract read
In one paragraph

Article in Journal of translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. PD-L1Journal of translational medicine · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. The role of CD133 in cancer: a concise review.Clinical and translational medicine · 2018
    Review
  10. Article
  11. A novel capillary nano-immunoassay for assessing androgen receptor splice variant 7 in plasma. Correlation with CD133 antigen expression in circulating tumor cells. A pilot study in prostate cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017
    Article
  12. Predictive Value of Circulating Tumor Cells for Evaluating Short- and Long-Term Efficacy of Chemotherapy for Breast Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edwin E ReyesCommittee on Immunology, The University of Chicago, Chicago, IL, USA.
Marc GillardDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, USA.
Ryan DugganFlow Cytometry Facility, The University of Chicago, Chicago, IL, USA.
Kristen WroblewskiDepartment of Public Health Sciences, The University of Chicago, Chicago, IL, USA.
Steven KregelCommittee on Cancer Biology, The University of Chicago, Chicago, IL, USA.
Masis IsikbayDepartment of Surgery, Section of Urology, The University of Chicago, Chicago, IL, USA.
Jacob KachDepartment of Surgery, Section of Urology, The University of Chicago, Chicago, IL, USA.
Hannah BrechkaCommittee on Cancer Biology, The University of Chicago, Chicago, IL, USA.
David J Vander WeeleDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, USA.
Russell Z SzmulewitzDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL, USA.
Donald J Vander GriendCommittee on Cancer Biology, The University of Chicago, Chicago, IL, USA; Department of Surgery, Section of Urology, The University of Chicago, Chicago, IL, USA.

Funding

SUPPRESSIVE ROLE OF ANDROGEN RESPONSE GENE CALRETICULIN IN PROSTATE CANCERP50CA090386 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, ZHOU · 2001 to 2013
$25.1M
Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A., HUSSAIN, MAHA H · 2015 to 2025
$19.9M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Function of the Stem Cell Transcription Factor Sox2 in Prostate CancerR01CA178431 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VANDER GRIEND, DONALD JAMES · 2014 to 2018
$1.9M
NCI NIH HHS P50 CA090386NCI NIH HHS P50 CA180995NCI NIH HHS R01 CA178431NCI NIH HHS T32 CA009594NIAID NIH HHS T32 AI007090
6 · The paper itself

Abstract

The function and clinical utility of stem cell markers in metastatic castration-resistant prostate cancer (mCRPC) remains unresolved, and their expression may confer important therapeutic opportunities for staging and therapy. In the adult human prostate, CD133 (PROM1) expression identifies infrequent prostate epithelial progenitor cells and putative cancer stem cells. Previous work demonstrated an association with CD133 and cancer cell proliferation using

Indexed as

androgen receptorCD133circulating tumor cellsmetastatic castration-resistance prostate cancerproliferation

Identifiers

PMID26753099
PMCPMC4704802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.