ArticleResearch in pharmaceutical sciences
Antispasmodic effect of Dracocephalum kotschyi hydroalcoholic extract on rat ileum contraction.
Article in Research in pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Phytochemical Diversity and Antioxidant Potential ofAntioxidants (Basel, Switzerland) · 2026Review
- A double-blind randomized clinical trial ofResearch in pharmaceutical sciences · 2023Article
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- In Vitro and In Vivo Anti-Toxoplasma Activities of Dracocephalum kotschyi Extract in Experimental Models of Acute Toxoplasmosis.Acta parasitologica · 2022Article
- Article
- Anti-inflammatory effect of apigenin and hydroalcoholic extract ofResearch in pharmaceutical sciences · 2017Article
- Comparison of antispasmodic effect of hydroalcoholic extract of Dracocephalum kotschyi Boiss. in rat uterus and ileum.Research in pharmaceutical sciences · 2016Article
- Cytotoxic and apoptogenic effects ofAvicenna journal of phytomedicineArticle
- Antidiarrhoeal assessment of hydroalcoholic and hexane extracts of Dracocephalum kotschyi Boiss. and apigenin in mice.Research in pharmaceutical sciencesArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dracocephalum kotschyi Boiss. (Labiatae) is a traditional medicine which is believed to have antispasmodic and analgesic activities. The antispasmodic action of D. kotschyi essential oil has been shown in a previous report. The objective of this research was to study antispasmodic activity of hydroalcoholic extract of D. kotschyi on ileum contractions. Hydroalcoholic extract was obtained from aerial part of D. kotschyi using percolation method. For antispasmodic studies, a portion of rat ileum was suspended under 1g tension in Tyrode's solution at 37 °C and gassed with O2. Effect of the D. kotschyi extract was assessed on ileum contractions induced by KCl (80 mM), acetylcholine (ACh, 500 nM) and electrical field stimulation (EFS). The D. kotschyi extract concentration dependently inhibited the response to KCl (IC50 =36 ± 5.1 μg/ml), ACh (IC50 =101 ± 9.5 μg/ml), EFS-1 (IC50 =96 ± 7.1 μg/ml) and EFS-2 (IC50 =53 ± 4.3 μg/ml). From this experiment it was concluded that D. kotschyi extract possessed potent antispasmodic activity. Therefore, identification of the active component(s) is (are) recommended in order to find the best lead compound for drug development.
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Identifiers
26752993PMC4691965W2151887718What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.