Evidence map›Paper›PMID 26752890›Full record

ArticleJournal of neurosciences in rural practice

Scrub typhus meningoencephalitis, a diagnostic challenge for clinicians: A hospital based study from North-East India.

M D Jamil, Masaraf Hussain, Monaliza Lyngdoh, Shriram Sharma, Bhupen Barman, P K Bhattacharya

Open access · goldAbstract read
In one paragraph

Article in Journal of neurosciences in rural practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Imaging in scrub typhus - a pictorial review.Abdominal radiology (New York) · 2026
    Review
  3. Article
  4. Abductor Palsy in Scrub Typhus: Authors' Reply.Indian journal of pediatrics · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Seroprevalence & seroincidence ofThe Indian journal of medical research · 2020
    Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M D JamilDepartment of Medicine, NEIGRIHMS, Shillong, Meghalaya, India.
Masaraf HussainDepartment of Neurology, NEIGRIHMS, Shillong, Meghalaya, India.
Monaliza LyngdohDepartment of Medicine, NEIGRIHMS, Shillong, Meghalaya, India.
Shriram SharmaDepartment of Neurology, NEIGRIHMS, Shillong, Meghalaya, India.
Bhupen BarmanDepartment of Medicine, NEIGRIHMS, Shillong, Meghalaya, India.
P K BhattacharyaDepartment of Medicine, NEIGRIHMS, Shillong, Meghalaya, India.
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledCentral nervous system (CNS) involvement is a known complication of scrub typhus which range from mild meningitis to frank meninigoencephalitis. AIMS AND

objectivesTo study the clinical feature, laboratory parameters and response to treatment of scrub typhus meningitis/meningoencephalitis. METHODS AND MATERIALS: This is a hospital based prospective observational study from North Eastern India. Diagnosis was based on clinical features and positive serological test (Weil's Felix test and IgM antibody card test).

results13 patients of scrub typhus with features of meningitis/meningoencephalitis were included. The mean duration of fever before presentation was 5.61±3.08 days and 4 (30.76 %) patients had eschar. Altered sensorium, headache, seizure and meningeal sign were present in 13 (100%), 13 (100%), 6 (46.15%) and 10 (76.92%) patients respectively. Mean CSF protein, glucose and Adenosine deaminase was 152.16±16.88mg/dl, 55.23±21.7mg/dl, and 16.98±7.37U/L respectively. Mean total count of CSF leukocyte and lymphocyte percentage was 46.07±131 cell/cumm and 98.66±3.09% respectively. Tablet doxycycline with or without injection azithromycin was used and that shows good response 15.38% of patients died and all of them had multi organ dysfunction.

conclusionMeningoencephalitis is a common manifestation of scrub typhus and diagnosis requires high degree of clinical suspicion which if diagnosed early and specific treatment started, patients usually recover completely with few complications.

Indexed as

Cerebrospinal fluidmeningoencephalitisscrub typhus

Identifiers

PMID26752890
PMCPMC4692003
OpenAlexW2286310851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.