Evidence map›Paper›PMID 26752870›Full record

ArticleJournal of global infectious diseases

Polymorphisms of Transporter Associated with Antigen Presentation, Tumor Necrosis Factor-α and Interleukin-10 and their Implications for Protection and Susceptibility to Severe Forms of Dengue Fever in Patients in Sri Lanka.

Anira N Fernando, Gathsaurie Neelika Malavige, Kuda Liyanage Nandika Perera, Sunil Premawansa, Graham S Ogg, Aruna Dharshan De Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of global infectious diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Host genetic control of mosquito-borne Flavivirus infections.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Anira N FernandoGenetech Research Institute, Colombo 08, Sri Lanka.
Gathsaurie Neelika MalavigeDepartment of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka; MRC Human Immnology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
Kuda Liyanage Nandika PereraGenetech Research Institute, Colombo 08, Sri Lanka.
Sunil PremawansaDepartment of Zoology, Faculty of Science, University of Colombo, Sri Lanka.
Graham S OggMRC Human Immnology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
Aruna Dharshan De SilvaGenetech Research Institute, Colombo 08, Sri Lanka; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Genetech (Sri Lanka) · LKMRC Human Immunology Unit · GBLa Jolla Institute for Immunology · USUniversity of Colombo · LK

Funding

Medical Research Council MC_UU_12010/5
6 · The paper itself

Abstract

contextTo date, a clear understanding of dengue disease pathogenesis remains elusive. Some infected individuals display no symptoms while others develop severe life-threatening forms of the disease. It is widely believed that host genetic factors influence dengue severity.

aimsThis study evaluates the relationship between certain polymorphisms and dengue severity in Sri Lankan patients. SETTINGS AND

designPolymorphism studies are carried out on genes for; transporter associated with antigen presentation (TAP), promoter of tumor necrosis factor-α (TNF-α), and promoter of interleukin-10 (IL-10). In other populations, TAP1 (333), TAP2 (379), TNF-α (-308), and IL-10 (-1082, -819, -592) have been associated with dengue and a number of different diseases. Data have not been collected previously for these polymorphisms for dengue patients in Sri Lanka. MATERIALS AND

methodsThe polymorphisms were typed by amplification refractory mutation system polymerase chain reaction in 107 dengue hemorrhagic fever (DHF) patients together with 62 healthy controls. STATISTICAL ANALYSIS USED: Pearson's Chi-square contingency table analysis with Yates' correction.

resultsNeither the TAP nor the IL-10 polymorphisms considered individually can define dengue disease outcome with regard to severity. However, the genotype combination, IL-10 (-592/-819/-1082) CCA/ATA was significantly associated with development of severe dengue in these patients, suggesting a risk factor to developing DHF. Also, identified is the genotype combination IL-10 (-592/-819/-1082) ATA/ATG which suggested a possibility for protection from DHF. The TNF-α (-308) GG genotype was also significantly associated with severe dengue, suggesting a significant risk factor.

conclusionsThe results reported here are specific to the Sri Lankan population. Comparisons with previous reports imply that data may vary from population to population.

Indexed as

Denguedengue hemorrhagic feverinterleukin-10transporter associated with antigen presentationtumor necrosis factor-α

Identifiers

PMID26752870
PMCPMC4693307
OpenAlexW2234971287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.