ArticleAnalytical chemistry2016
Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses.Advances in experimental medicine and biology · 2026Review
- Development and Modification of Ion Mobility Mass Spectrometry Instrumentation for Enhanced Analysis of Biological Molecules.Journal of the American Society for Mass Spectrometry · 2025Review
- The Future of Proteomics is Up in the Air: Can Ion Mobility Replace Liquid Chromatography for High Throughput Proteomics?Journal of proteome research · 2024Review
- Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- High-resolution separation of bioisomers using ion cloud profiling.Nature communications · 2023Article
- Development of a Structure for Lossless Ion Manipulations (SLIM) High Charge Capacity Array of Traps.Analytical chemistry · 2023Article
- Resolving Power and Collision Cross Section Measurement Accuracy of a Prototype High-Resolution Ion Mobility Platform Incorporating Structures for Lossless Ion Manipulation.Journal of the American Society for Mass Spectrometry · 2021Article
- Assessing Collision Cross Section Calibration Strategies for Traveling Wave-Based Ion Mobility Separations in Structures for Lossless Ion Manipulations.Analytical chemistry · 2020Article
- Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules.Methods in molecular biology (Clifton, N.J.) · 2020Review
- A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations.The Analyst · 2019Article
- Traveling-Wave-Based Electrodynamic Switch for Concurrent Dual-Polarity Ion Manipulations in Structures for Lossless Ion Manipulations.Analytical chemistry · 2019Article
- Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses.Analytical and bioanalytical chemistry · 2019Article
- Dual Polarity Ion Confinement and Mobility Separations.Journal of the American Society for Mass Spectrometry · 2019Article
- Principles of Ion Selection, Alignment, and Focusing in Tandem Ion Mobility Implemented Using Structures for Lossless Ion Manipulations (SLIM).Journal of the American Society for Mass Spectrometry · 2019Article
- New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells.The Analyst · 2019Review
- Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM).International journal of mass spectrometry · 2018Article
- A Hybrid Constant and Oscillatory Field Ion Mobility Analyzer Using Structures for Lossless Ion Manipulations.Journal of the American Society for Mass Spectrometry · 2018Article
- Benchmark Comparison for a Multi-Processing Ion Mobility Calculator in the Free Molecular Regime.Journal of the American Society for Mass Spectrometry · 2017Article
- Distinguishing d- and l-aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry.Chemical communications (Cambridge, England) · 2017Article
- Design of a TW-SLIM Module for Dual Polarity Confinement, Transport, and Reactions.Journal of the American Society for Mass Spectrometry · 2017Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
The integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performing reactions, accumulating ions, and increasing analytical measurement sensitivity. The development of Structures for Lossless Ion Manipulations (SLIM) offers the potential for ion manipulations in an extended and more effective manner, while opening opportunities for many more complex sequences of manipulations. Here, we demonstrate an ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species. The operation and optimization of the SLIM switch/tee and trap are described and demonstrated for the enrichment of the low abundance ions. A linear improvement in ion intensity was observed with the number of trapping/accumulation events using the SLIM trap, illustrating its potential for enhancing the sensitivity of low abundance or targeted species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.