ArticleNeuropsychology2016
Gray matter integrity within regions of the dorsolateral prefrontal cortical-subcortical network predicts executive function and fine motor dexterity in spina bifida.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The Influence of Hobby Engagement on Cognitive Function Among Older Adults: A Population-Based Cohort Study Using Statistical Analysis and Machine Learning Predictions.Neurology international · 2025Article
- Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A scoping review of cognition in spina bifida and its consequences for activity and participation throughout life.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Emerging magnetic resonance imaging techniques in open spina bifida in utero.European radiology experimental · 2021Review
- Cognitive and motor function in adults with spina bifida myelomeningocele: a pilot study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- An mHealth App for Users with Dexterity Impairments: Accessibility Study.JMIR mHealth and uHealth · 2019Article
- Exploration of gray matter correlates of cognitive training benefit in adolescents with chronic traumatic brain injury.NeuroImage. Clinical · 2019Article
- Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele.Neuropsychology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThis study examined microstructural properties of cortical and subcortical gray matter components of the dorsolateral prefrontal (DLPFC) cortical-subcortical circuit in relation to parent-rated executive function and fine motor dexterity performance in youth with spina bifida myelomeningocele (SBM). Aberrant gray matter integrity of the DLPFC, basal ganglia nuclei, and thalamus were hypothesized to differentially relate to neurobehavioral outcomes.
methodsForty-nine youth between 8 and 18 years (M = 12.34) old with SBM underwent a 3T MRI including diffusion tensor imaging. Neurobehavioral measures of parent-rated executive function and fine motor dexterity were obtained from a standardized neuropsychological evaluation. Relations among indices of gray matter microstructural integrity (mean diffusivity [MD], fractional anisotropy [FA], cortical thickness) and neurobehavior were examined using 3 correlational methods to enhance reliability of brain-behavior relations.
resultsIn SBM, higher FA values in the caudate were associated with poorer behavioral regulation. Higher FA values in the putamen and greater DLPFC thickness were both associated with poorer fine motor dexterity.
conclusionBehavioral regulation and FA in the caudate related to behavioral inhibition in SBM. Similarly, associations between fine motor dexterity and indices of gray matter integrity in the putamen and DLPFC support fronto-striatal involvement in motor control in SBM. Examination of these neurobehavioral correlates revealed a pattern of attenuated behavioral impairments when gray matter structure was more similar to that of typically developing youth. (PsycINFO Database Record
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