ArticlePloS one2016
Aberrant Wound Healing in an Epidermal Interleukin-4 Transgenic Mouse Model of Atopic Dermatitis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Hydrogels modified with IL4 or SDF1 mimicking peptides serve as a supportive environment for human iPSC-derived myoblasts.Stem cell research & therapy · 2026Article
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- Mineral coated microparticles delivering Interleukin-4, Interleukin-10, and Interleukin-13 reduce inflammation and improve function after spinal cord injury in a rat.Experimental neurology · 2025Article
- Phytochemical Analysis and Biological Activities of Flavonoids and Anthraquinones fromPlants (Basel, Switzerland) · 2025Article
- Single-cell analysis of age-related changes in leukocytes of diabetic mouse hindpaws.Cellular and molecular life sciences : CMLS · 2024Article
- Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds.NPJ Regenerative medicine · 2023Article
- Article
- Microfibril-associated protein 5 and the regulation of skin scar formation.Scientific reports · 2023Article
- Glycomacropeptide Protects against Inflammation and Oxidative Stress, and Promotes Wound Healing in an Atopic Dermatitis Model of Human Keratinocytes.Foods (Basel, Switzerland) · 2023Article
- The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis.Biomimetics (Basel, Switzerland) · 2023Review
- Review
- Effects of Histamine and the α-Tocopherol Metabolite α-13'-COOH in an Atopic Dermatitis Full-Thickness Skin Model.Molecules (Basel, Switzerland) · 2023Article
- Neutralization of excessive CCL28 improves wound healing in diabetic mice.Frontiers in pharmacology · 2023Article
- Macrophage polarity and wound age determination.Scientific reports · 2022Article
- Article
- Chronic Non-Healing Ulcers Associated with Atopic Inflammation: A Case Report.Clinical, cosmetic and investigational dermatology · 2022Article
- The Wound Healing Peptide, AES16-2M, Ameliorates Atopic Dermatitis In Vivo.Molecules (Basel, Switzerland) · 2021Article
- Pigment epithelium-derived factor attenuates angiogenesis and collagen deposition in hypertrophic scars.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020Article
- CCL28-induced CCR10/eNOS interaction in angiogenesis and skin wound healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- LDL induces cholesterol loading and inhibits endothelial proliferation and angiogenesis in Matrigels: correlation with impaired angiogenesis during wound healing.American journal of physiology. Cell physiology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Wound healing in a pre-existing Th2-dominated skin milieu was assessed by using an epidermal specific interleukin-4 (IL-4) transgenic (Tg) mouse model, which develops a pruritic inflammatory skin condition resembling human atopic dermatitis. Our results demonstrated that IL-4 Tg mice had delayed wound closure and re-epithelialization even though these mice exhibited higher degrees of epithelial cell proliferation. Wounds in IL-4 Tg mice also showed a marked enhancement in expression of inflammatory cytokines/chemokines, elevated infiltration of inflammatory cells including neutrophils, macrophages, CD3+ lymphocytes, and epidermal dendritic T lymphocytes. In addition, these mice exhibited a significantly higher level of angiogenesis as compared to wild type mice. Furthermore, wounds in IL-4 Tg mice presented with larger amounts of granulation tissue, but had less expression and deposition of collagen. Taken together, an inflamed skin condition induced by IL-4 has a pronounced negative influence on the healing process. Understanding more about the pathogenesis of wound healing in a Th2- dominated environment may help investigators explore new potential therapeutic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.