SynthesisPloS one2016
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Investigating the Inflammatory Link Between Vitamin D and Hidradenitis Suppurativa: A Systematic Review and Causal Inference Analysis.International journal of molecular sciences · 2026Pooled it
- The impact of exercise on inflammatory biomarkers: an umbrella review of systematic reviews and meta-analyses.Frontiers in immunology · 2026Pooled it
- Vitamin D deficiency in rheumatoid arthritis patients of India - a single-arm meta-analysis.African health sciences · 2023Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Serum Vitamin D Level and the Risk of Urinary Tract Infection in Children: A Systematic Review and Meta-Analysis.Frontiers in public health · 2021Pooled it
- Pooled it
- Pooled it
- Guideline
- The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Vitamin D status and the immune assessment in 22q11.2 deletion syndrome.Clinical and experimental immunology · 2020Trial
- Trial
- Effects of Vitamin D on Epigenetics, Seasonality, and Management of Rheumatoid Arthritis.Nutrients · 2026Review
- Vitamin D Receptor Polymorphisms and Rheumatoid Arthritis Risk: A Systematic Review and Meta-Analysis Evaluating the Moderating Effects of Ethnicity, Bone Erosion, and Classification Criteria.Archives of rheumatology · 2026Article
- The Role of Microbiome and Diet on Disease Activity and Immune-Inflammatory Status in Rheumatoid Arthritis.Nutrients · 2026Review
- Comparison of serum 25-hydroxyvitamin D levels between patients with multiple chemical sensitivity and healthy controls: A case-control study.Scientific reports · 2026Article
- SMART model-based social marketing intervention to improve vitamin d supplementation adherence in female university students: a quasi-experimental mixed-methods study.Scientific reports · 2026Article
- Observational
- The Role of Vitamin D in Autoimmune Diseases.International journal of molecular sciences · 2026Review
- Correlations Between Serum Vitamin D, Synovial Succinic Acid Levels and Disease Activity in Patients with Rheumatoid Arthritis.Journal of inflammation research · 2026Article
- Correlation between double-stranded DNA and rheumatoid arthritis.Central-European journal of immunology · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evidence from epidemiological studies concerning the relationship between serum vitamin D concentrations and rheumatoid arthritis (RA) is inconsistent. This meta-analysis is aimed at determining the magnitude of the correlation between this common autoimmune disease and vitamin D, an important nutrient known to dampen adaptive immune responses.
methodsThrough multiple search strategies, relevant literature was identified and evaluated for quality before May 16 2015. Data extracted from eligible studies was synthesized to calculate pooled correlation coefficient (r), mean difference (MD) and odds ratio (OR). The Venice criteria were applied to assess the credibility of the evidence for each statistically significant association.
resultsA total of 24 reports involving 3489 patients were selected for analysis. RA patients had lower vitamin D levels than healthy controls (MD:-16.52 nmol/L, 95% confidence intervals [CI]:-18.85 to -14.19 nmol/L). There existed a negative relationship between serum 25-hydroxyvitamin D (25OHD) level and disease activity index, e.g. 25OHD vs. Disease Activity Score in 28 joints (DAS28): r = -0.13, 95% CI -0.16 to -0.09; 25OHD vs. C-reactive protein: r = -0.12, 95% CI -0.23 to -0.00. Additionally, latitude-stratified subgroup analysis yielded a relatively stronger negative correlation between 25OHD and DAS28 in low-latitude areas. This inverse relationship also appeared more significant in developing countries than in developed countries. No publication bias was detected.
conclusionRA patients had lower vitamin D values than healthy controls. There was a negative association between serum vitamin D and RA disease activity. However, more strictly controlled studies are needed to validate these findings.
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