ArticlePLoS genetics2016
Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- OutbredbioRxiv : the preprint server for biology · 2026Article
- Private QTLs and the genetic architecture of hierarchical size traits: from body size to sex-specific plasticity.G3 (Bethesda, Md.) · 2026Article
- Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.PLoS genetics · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.bioRxiv : the preprint server for biology · 2025Article
- Machine learning methods for gene regulatory network inference.Briefings in bioinformatics · 2025Review
- Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parentbioRxiv : the preprint server for biology · 2025Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- Deep orange gene editing triggers temperature-sensitive lethal phenotypes in Ceratitis capitata.BMC biotechnology · 2024Article
- Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila.PLoS genetics · 2023Article
- Influence of Heat Treatment on Tea Polyphenols and Their Impact on Improving Heat Tolerance inFoods (Basel, Switzerland) · 2023Article
- Higher-order epistasis shapes natural variation in germ stem cell niche activity.Nature communications · 2023Article
- Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body.PLoS genetics · 2023Article
- Long-term evolution of quantitative traits in the Drosophila melanogaster species subgroup.Genetica · 2022Article
- Genome-Wide Analysis inGenes · 2022Article
- RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila.PLoS genetics · 2021Article
- GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production.Current biology : CB · 2020Article
- Characterization of the Genetic Architecture Underlying Eye Size Variation WithinG3 (Bethesda, Md.) · 2020Article
- Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity.G3 (Bethesda, Md.) · 2020Article
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5 authors.
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Abstract
Organismal size depends on the interplay between genetic and environmental factors. Genome-wide association (GWA) analyses in humans have implied many genes in the control of height but suffer from the inability to control the environment. Genetic analyses in Drosophila have identified conserved signaling pathways controlling size; however, how these pathways control phenotypic diversity is unclear. We performed GWA of size traits using the Drosophila Genetic Reference Panel of inbred, sequenced lines. We find that the top associated variants differ between traits and sexes; do not map to canonical growth pathway genes, but can be linked to these by epistasis analysis; and are enriched for genes and putative enhancers. Performing GWA on well-studied developmental traits under controlled conditions expands our understanding of developmental processes underlying phenotypic diversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.