ArticlePloS one2016
Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis?
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06235346 (Ocular Effects of Synthetic Cannabinoids), which is not on this map. Cited by 118 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ocular Effects of Synthetic Cannabinoids: A Case-control Study
Who cites it
118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Choroidal vascularity index is independent of ocular and image-based factors in healthy eyes: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Choroidal binarization analysis: clinical application.International ophthalmology · 2019Pooled it
- Effect of shorter silicone oil tamponade time on visual function recovery and associated factors in patients with rhegmatogenous retinal detachment.BMC ophthalmology · 2026Trial
- Impact of Optical Coherence Tomography Scan Pattern and Chorio-Scleral Interface Delineation on Choroidal Vascularity Index Measurements.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Bilateral choroidal thinning during unilateral aflibercept for neovascular age-related macular degeneration: 5-year mixed-effects analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Spatial Selective Choroidal Stromal and Vascular Changes in Intermediate AMD: Insights From High-Density Optical Coherence Tomography Analysis.Investigative ophthalmology & visual science · 2026Article
- A deep learning-based pachychoroid index based on choroidal image patterns of central serous chorioretinopathy using enhanced-depth-imaging optical coherence tomography.Japanese journal of ophthalmology · 2026Observational
- Choroidal vascularization in polycystic ovary syndrome: an optical coherence tomography study.International ophthalmology · 2026Article
- Investigation of laser peripheral iridotomy characteristics using the ImageJ program on anterior segment parameters.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Peripapillary Retinal and Choroidal Vasculature in Patients with Diabetes of Different Durations without Clinical Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Evaluation of retina and choroidInternational journal of ophthalmology · 2026Article
- Evaluation of longitudinal changes in choroidal thickness during pregnancy and postpartum using widefield swept-source optical coherence tomography.Scientific reports · 2025Observational
- Association between serous macular detachment and choroidal vascular architecture in treatment-Naïve branch retinal vein occlusion.International ophthalmology · 2025Article
- Evaluation of choroidal vascularity index and choroidal thickness in patients with primary Sjögren's syndrome.International ophthalmology · 2025Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Assessment of choroidal vascularity index in juvenile idiopathic arthritis: implications for disease monitoring.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Choroidal vascular characteristics in anisometropic amblyopia: a comparative analysis.BMC ophthalmology · 2025Article
- Comparison of choroidal vascularity index in rhegmatogenous retinal detachment: impact of silicone-oil vs. gas tamponade following pars plana vitrectomy.BMC ophthalmology · 2025Article
- Choroidal profile in patients with inactive thyroid-associated ophthalmopathy.BMC ophthalmology · 2025Article
- Relationship between choroidal structure and myocardial collateral flow regulation in acute and chronic coronary heart disease.International ophthalmology · 2025Observational
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo compute choroidal vascularity index (CVI) using an image binarization tool on enhanced depth imaging (EDI)-optical coherence tomography (OCT) scans as a non-invasive optical tool to monitor progression in panuveitis and to investigate the utility of volumetric data from EDI-OCT scans using custom image analysis software. MATERIALS AND
methodsIn this retrospective cohort study, segmented EDI-OCT scans of both eyes in 19 patients with panuveitis were taken at baseline and at 3-month follow-up and were compared with EDI-OCT scans of normal eyes. Subfoveal choroidal area was segmented into luminal (LA) and stromal interstitial area (SA). Choroidal vascularity index (CVI) was defined as the proportion of LA to the total circumscribed subfoveal choroidal area (TCA).
resultsThe mean choroidal thickness was 265.5±100.1μm at baseline and 278.4±102.6μm at 3 months follow up (p = 0.06). There was no statistically significant difference in TCA between study and control eyes (p = 0.08). CVI in the control group was 66.9±1.5% at baseline and 66.4±1.5% at follow up. CVI was 74.1±4.7% at baseline and 69.4±4.8% at 3 months follow up for uveitic eyes (p<0.001). The % change in CVI was 6.2 ±3.8 (4.3 to 8.0) for uveitic eyes, which was significantly higher from % change in CVI for control eyes (0.7±1.1, 0.2 to 1.3, p<0.001).
conclusionThe study reports composite OCT-derived parameters and CVI as a possible novel tool in monitoring progression in panuveitis. CVI may be further validated in larger studies as a novel optical tool to quantify choroidal vascular status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.