ArticleSubstance abuse
Genes involved in stress response and alcohol use among high-risk African American youth.
Article in Substance abuse. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Peripheral blood transcriptomic profiling of molecular mechanisms commonly regulated by binge drinking and placebo effects.Scientific reports · 2024Article
- Genetic Risk, Neighborhood Characteristics, and Behavioral Difficulties Among African American Adolescents Living in Very Low-Income Neighborhoods.Research on child and adolescent psychopathology · 2023Article
- Racial/ethnic discrimination, ADH1B*3, and coping-motivated drinking among Black college students.The American journal on addictions · 2022Article
- Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.Journal of youth and adolescence · 2020Article
- Trends in Alcohol Use Behaviors by Sexual Identity and Behavior Among High School Students, 2007-2017.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Article
- Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents.International journal of environmental research and public health · 2019Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.Pharmacogenomics · 2018Article
- Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students.The American journal of drug and alcohol abuse · 2018Article
- Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.The American journal on addictions · 2017Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundGenetic and environmental factors influence substance use behaviors in youth. One of the known environmental risk factors is exposure to life stressors. The aim of this project is to study the interaction between NR3C1 and CRHBP, genes thought to be involved in stress pathways, exposure to stressful life events, and adolescent alcohol use/misuse.
methodsThe sample included 541 African American individuals (ages 13-18) from the Genes, Environment, and Neighborhood Initiative, a subset of the Mobile Youth Survey sample from whom DNA and more extensive phenotypic data were collected. Participants were selected from high-poverty neighborhoods in Mobile, Alabama, with potential exposure to a variety of extreme life stressors.
resultsA measure of stressful life events was significantly predictive of alcohol use/misuse. In addition, this association was significantly dependent upon the number of putative risk variants at rs1715749, a single-nucleotide polymorphism (SNP) in CRHBP (P ≤ .006). There was no significant interaction between NR3C1 and stressful life events with respect to alcohol use/misuse, after taking into account multiple testing.
conclusionsThese findings suggest that CRHBP variants are potentially relevant for adolescent alcohol use/misuse among African American youth populations being reared within the context of stressful life events and warrant replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.